ArticleThe Journal of physiology1996
The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 148 citations in OpenAlex.
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Activation of Smooth Muscle KInternational journal of molecular sciences · 2025Article
- Decreased inward rectifier and voltage-gated KThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020Article
- Inhibition of vascular smooth muscle inward-rectifier KAmerican journal of physiology. Renal physiology · 2017Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Regulation of Coronary Blood Flow.Comprehensive Physiology · 2017Review
- Nortriptyline, a tricyclic antidepressant, inhibits voltage-dependent KThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2017Article
- Conducted dilatation to ATP and KActa physiologica (Oxford, England) · 2017Article
- Article
- Low-Dimensional Models of "Neuro-Glio-Vascular Unit" for Describing Neural Dynamics under Normal and Energy-Starved Conditions.Frontiers in neurology · 2016Article
- Unique gene program of rat small resistance mesenteric arteries as revealed by deep RNA sequencing.Physiological reports · 2015Article
- Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow.Microcirculation (New York, N.Y. : 1994) · 2015Review
- Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion.Microvascular research · 2015Article
- Smooth muscle contractile diversity in the control of regional circulations.American journal of physiology. Heart and circulatory physiology · 2014Review
- Potassium channels and uterine vascular adaptation to pregnancy and chronic hypoxia.Current vascular pharmacology · 2013Review
- Intercellular communication in the vascular wall: a modeling perspective.Microcirculation (New York, N.Y. : 1994) · 2012Review
- Vascular smooth muscle phenotypic diversity and function.Physiological genomics · 2010Review
- Diabetes-induced inhibition of voltage-dependent calcium channels in the retinal microvasculature: role of spermine.Investigative ophthalmology & visual science · 2010Article
- Physiological role of inward rectifier K(+) channels in vascular smooth muscle cells.Pflugers Archiv : European journal of physiology · 2008Review
- Changes in inward rectifier K+ channels in hepatic stellate cells during primary culture.Yonsei medical journal · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Whole-cell potassium currents were studied in single smooth muscle cells enzymatically isolated from pig coronary arteries. 2. In cells isolated from small diameter branches of the left anterior descending coronary artery (LAD), an inward rectifier potassium current (IK(IR)) was identified, which was inhibited by extracellular barium ions, suggesting the presence of inward rectifier potassium (KIR) channels. 3. The conductance for IK(IR) measured in 6, 12, 60 and 140 mM extracellular potassium was a function of membrane potential and the extracellular potassium concentration. 4. On hyperpolarization, IK(IR) activated along an exponential time course with a time constant that was voltage dependent. 5. Inward rectifier current was compared in cells isolated from coronary vessels taken from different points along the vascular tree. Current density was greater in cells isolated from small diameter coronary arteries; at -140 mV it was -20.5 +/- 4.4 pA pF-1 (n = 23) in 4th order branches of the LAD, but -0.8 +/- 0.2 pA pF-1 (n = 11) in the LAD itself. 6. In contrast to IK(IR), there was little effect of arterial diameter on the density of voltage-dependent potassium current; densities at +30 mV were 12.8 +/- 1.3 pA pF-1 (n = 19) in 4th order branches and 17.4 +/- 3.1 pA pF-1 (n = 11) in the LAD. 7. We conclude that KIR channels are present in pig coronary arteries, and that they are expressed at a higher density in small diameter arteries. The presence of an enhanced IK(IR) may have functional consequences for the regulation of cell membrane potential and tone in small coronary arteries.
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