ArticleThe Journal of physiology1996
The sulphonylurea receptor confers diazoxide sensitivity on the inwardly rectifying K+ channel Kir6.1 expressed in human embryonic kidney cells.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 78 citations in OpenAlex.
- Endogenous ion channels expressed in human embryonic kidney (HEK-293) cells.Pflugers Archiv : European journal of physiology · 2022Review
- Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity.eLife · 2021Article
- Cyanidin Stimulates Insulin Secretion and Pancreatic β-Cell Gene Expression through Activation of l-type Voltage-Dependent CaNutrients · 2017Article
- KATP Channels in the Cardiovascular System.Physiological reviews · 2016Review
- Voltage-dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells.Glia · 2015Article
- ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons.Brain research · 2007Article
- Pre- and postsynaptic ATP-sensitive potassium channels during metabolic inhibition of rat hippocampal CA1 neurons.The Journal of physiology · 2002Article
- Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells.British journal of pharmacology · 2000Article
- Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A.British journal of pharmacology · 1999Article
- Cell-type specific expression of ATP-sensitive potassium channels in the rat hippocampus.The Journal of physiology · 1999Article
- Basal activation of ATP-sensitive potassium channels in murine colonic smooth muscle cell.Biophysical journal · 1998Article
- Cystic fibrosis transmembrane conductance regulator mediates sulphonylurea block of the inwardly rectifying K+ channel Kir6.1.The Journal of physiology · 1998Article
- Modulation of reconstituted ATP-sensitive K(+)-channels by GTP-binding proteins in a mammalian cell line.The Journal of physiology · 1998Article
- Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts.The Journal of clinical investigation · 1997Article
- The interaction of nucleotides with the tolbutamide block of cloned ATP-sensitive K+ channel currents expressed in Xenopus oocytes: a reinterpretation.The Journal of physiology · 1997Article
- The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide.The EMBO journal · 1997Article
- Properties of cloned ATP-sensitive K+ currents expressed in Xenopus oocytes.The Journal of physiology · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
1. We have examined the effects of diazoxide and intracellular ATP (ATPi) on whole-cell currents in HEK293 cells transfected transiently with the inwardly rectifying K+ channel Kir6.1 (uKATP1) or cotransfected with Kir6.1 and the sulphonylurea receptor (SUR1). 2. Kir6.1 currents were unaffected by the K+ channel opener diazoxide or by dialysis with 0.3 mM ATPi. 3. Kir6.1-SUR1 currents increased in amplitude when cells were dialysed with 0.3 mM ATP, but not with 5 mM ATP. This activation may be explained by the loss of endogenous ATP from the cell when the intracellular solution contains 0.3 mM ATP. Kir6.1-SUR1 currents were also activated by diazoxide; this activation was greater with 0.3 mM ATP1 than with 5 mM ATP1. 4. We conclude that SUR1 is required to confer both diazoxide and ATP sensitivity on Kir6.1.
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