ArticleJournal of clinical microbiology1996
Diagnosis of extrapulmonary tuberculosis by Gen-Probe amplified Mycobacterium tuberculosis direct test.
Article in Journal of clinical microbiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Pooled it
- Nucleic acid amplification tests in the diagnosis of tuberculous pleuritis: a systematic review and meta-analysis.BMC infectious diseases · 2004Pooled it
- Rapid identification of Mycobacterium tuberculosis complex on urine samples by Gen-Probe amplification test.Urological research · 1997Trial
- Methods for rapid diagnosis of meningitis etiology in adults.Biomarkers in medicine · 2020Review
- Comparison of amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis.Journal of clinical microbiology · 2014Article
- Use of amplified Mycobacterium tuberculosis direct test (Gen-probe Inc., San Diego, CA, USA) in the diagnosis of tubercular synovitis and early arthritis of knee joint.Indian journal of orthopaedics · 2012Article
- Comparison of two molecular methods for rapid diagnosis of extrapulmonary tuberculosis.Journal of clinical microbiology · 2011Article
- Clinical evaluation of the gen-probe amplified mycobacterium tuberculosis direct test for rapid diagnosis of tuberculosis lymphadenitis.Journal of clinical microbiology · 2004Article
- Improved sensitivity of nucleic acid amplification for rapid diagnosis of tuberculous meningitis.Journal of clinical microbiology · 2004Article
- Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy.Journal of clinical microbiology · 2004Article
- Rapid diagnosis of extrapulmonary tuberculosis by PCR: impact of sample preparation and DNA extraction.Journal of clinical microbiology · 2003Article
- Tuberculous orchiepididymitis diagnosed by nucleic acid amplification test: a case report.International urology and nephrology · 2003Article
- Inhibitory effect of Alpha-Tec XPR-plus phosphate buffer on the enhanced Gen-Probe Amplified Mycobacterium Tuberculosis Direct test.Journal of clinical microbiology · 1999Article
- Rapid diagnosis of extrapulmonary tuberculosis by ligase chain reaction amplification.Journal of clinical microbiology · 1998Article
- Identification of a new DNA region specific for members of Mycobacterium tuberculosis complex.Journal of clinical microbiology · 1998Article
- Comparative evaluation of initial and new versions of the Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test for direct detection of Mycobacterium tuberculosis in respiratory and nonrespiratory specimens.Journal of clinical microbiology · 1998Article
- Comparison of PCR, culture, and histopathology for diagnosis of tuberculous pericarditis.Journal of clinical microbiology · 1997Article
- Direct detection of Mycobacterium tuberculosis complex in nonrespiratory specimens by Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test.Journal of clinical microbiology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A total of 294 specimens collected from nonrespiratory sites of 268 patients were tested for direct detection of Mycobacterium tuberculosis complex by the Gen-Probe Amplified Mycobacterium tuberculosis Direct Test (AMTD). The specimens included ascitic, pleural, pericardial, and synovial fluids, abscess aspirates, and tissue and lymph node biopsy samples, as well as gastric aspirates and cerebrospinal fluid samples. All samples were processed by the N-acetyl-L-cysteine-sodium hydroxide decontamination procedure prior to testing. Twenty samples showed acid-fast bacilli on auramine staining, and 48 samples were positive by AMTD, 9 of which were negative for M. tuberculosis complex by culture. After reviewing the patients clinical charts to resolve discrepancies, the test result of one cerebrospinal fluid sample was considered to be false positive by AMTD. The overall sensitivity, specificity, positive predictive value, and negative predictive value were 83.9, 99.6, 97.9, and 96.3%, respectively. No significant differences were found when AMTD results obtained with specimens of nonrespiratory origin were compared with assay results obtained with samples of respiratory origin (P > 0.05). In conclusion, our results demonstrate that AMTD performs equally well with all types of specimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.