ArticleMolecular biology of the cell1996
The dynamics of coiled bodies in the nucleus of adenovirus-infected cells.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with the snRNP biogenesis machinery.Oncogene · 2023Article
- The cancer testis antigen TDRD1 regulates prostate cancer proliferation by associating with snRNP biogenesis machinery.Research square · 2023Article
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- Article
- Heat and chilling stress induce nucleolus morphological changes.Journal of plant research · 2019Article
- Towards an understanding of regulating Cajal body activity by protein modification.RNA biology · 2017Review
- Automatic detection and measurement of viral replication compartments by ellipse adjustment.Scientific reports · 2016Article
- Morphological, Biochemical, and Functional Study of Viral Replication Compartments Isolated from Adenovirus-Infected Cells.Journal of virology · 2016Article
- Nuclear actin and myosins in adenovirus infection.Experimental cell research · 2015Article
- An intranucleolar body associated with rDNA.Chromosoma · 2011Article
- The nucleolus under stress.Molecular cell · 2010Review
- Phosphorylation and the Cajal body: modification in search of function.Archives of biochemistry and biophysics · 2010Review
- UV-induced fragmentation of Cajal bodies.The Journal of cell biology · 2006Article
- FLASH is an essential component of Cajal bodies.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Identification and dynamics of Cajal bodies in relation to karyosphere formation in scorpionfly oocytes.Chromosoma · 2005Article
- Cajal bodies and coilin--moving towards function.The Journal of cell biology · 2002Review
- Large-scale isolation of Cajal bodies from HeLa cells.Molecular biology of the cell · 2002Article
- The spinal muscular atrophy disease gene product, SMN: A link between snRNP biogenesis and the Cajal (coiled) body.The Journal of cell biology · 1999Article
- Coilin shuttles between the nucleus and cytoplasm in Xenopus oocytes.Molecular biology of the cell · 1999Article
- The movement of coiled bodies visualized in living plant cells by the green fluorescent protein.Molecular biology of the cell · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coiled body is a specific intranuclear structure of unknown function that is enriched in splicing small nuclear ribonucleoproteins (snRNPs). Because adenoviruses make use of the host cell-splicing machinery and subvert the normal subnuclear organization, we initially decided to investigate the effect of adenovirus infection on the coiled body. The results indicate that adenovirus infection induces the disassembly of coiled bodies and that this effect is probably secondary to the block of host protein synthesis induced by the virus. Furthermore, coiled bodies are shown to be very labile structures, with a half-life of approximately 2 h after treatment of HeLa cells with protein synthesis inhibitors. After blocking of protein synthesis, p80 coilin was detected in numerous microfoci that do not concentrate snRNP. These structures may represent precursor forms of the coiled body, which goes through a rapid cycle of assembly/disassembly in the nucleus and requires ongoing protein synthesis to reassemble.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.