ArticleThe EMBO journal1996
Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 82 citations in OpenAlex.
- A coregulator shift, rather than the canonical switch, underlies thyroid hormone action in the liver.Genes & development · 2021Article
- Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone.Stem cell reports · 2021Article
- No Dataset Left Behind: Mechanistic Insights into Thyroid Receptor Signaling Through Transcriptomic Consensome Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2020Article
- Maternal hormonal milieu influence on fetal brain development.Brain and behavior · 2018Review
- Influence of maternal thyroid hormones during gestation on fetal brain development.Neuroscience · 2017Review
- Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine.Neuroscience and biobehavioral reviews · 2015Review
- An exploratory study of the association between thyroid hormone and survival of amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
- Role of maternal thyroid hormones in the developing neocortex and during human evolution.Frontiers in neuroanatomy · 2013Article
- Structural and functional alterations in the hippocampus due to hypothyroidism.Metabolic brain disease · 2010Review
- Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180.BMC neuroscience · 2010Article
- DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Multigenic control of thyroid hormone functions in the nervous system.Molecular and cellular endocrinology · 2008Review
- Thyroid hormone regulates the expression of SNAP-25 during rat brain development.Molecular and cellular biochemistry · 2008Article
- Functional analysis of basic transcription element binding protein by gene targeting technology.Molecular and cellular biology · 2003Article
- Current perspectives on the role of thyroid hormone in growth and development of cerebellum.Cerebellum (London, England) · 2003Review
- Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Action of thyroid hormone in brain.Journal of endocrinological investigation · 2002Review
- Thyroid hormone regulates reelin and dab1 expression during brain development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone (T3) is a main regulator of brain development acting as a transcriptional modulator. However, only a few T3-regulated brain genes are known. Using an improved whole genome PCR approach, we have isolated seven clones encoding sequences expressed in neonatal rat brain which are under the transcriptional control of T3. Six of them, including the neural cell adhesion molecule NCAM, alpha-tubulin and four other unidentified sequences (RBA3, RBA4, RBB3 and RBB5) were found to be upregulated in the hypothyroid brain, whereas another (RBE7) was downregulated. Binding sites for the T3 receptor (T3R/c-erbA) were identified in the isolated clones by gel-shift and footprinting assays. Sites in the NCAM (in an intron), alpha-tubulin (in an exon) and RBA4 clones mediated transcriptional regulation by T3 when inserted upstream of a reporter construct. However, no effect of the NCAM clone was found when located downstream of another reporter gene. Northern blotting and in situ hybridization studies showed a higher expression of NCAM in the brain of postnatal hypothyroid rats. Since NCAM is an important morphoregulatory molecule, abnormal NCAM expression is likely to contribute to the alterations present in the brain of thyroid-deficient humans and experimental animals.
Indexed as
Identifiers
8861959PMC452156W1881188846What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.