ArticleThe EMBO journal1996
Erythropoietin-induced erythroid differentiation of the human erythroleukemia cell line TF-1 correlates with impaired STAT5 activation.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 83 citations in OpenAlex.
- Choosing the Right Cell Line for Acute Myeloid Leukemia (AML) Research.International journal of molecular sciences · 2023Review
- RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia.Leukemia · 2022Article
- Enhanced Cell-Based Detection of Parvovirus B19V Infectious Units According to Cell Cycle Status.Viruses · 2020Article
- The PAX-SIX-EYA-DACH network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis.Development (Cambridge, England) · 2020Article
- SOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review.Frontiers in microbiology · 2017Review
- Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Selection of antibodies that regulate phenotype from intracellular combinatorial antibody libraries.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Establishment of an erythroid cell line from primary CD36+ erythroid progenitor cells.Experimental hematology · 2010Article
- Sumoylation regulates interaction of FOG1 with C-terminal-binding protein (CTBP).The Journal of biological chemistry · 2010Article
- Article
- Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis.Carcinogenesis · 2010Article
- Temporal regulation of Stat5 activity in determination of cell differentiation program.Biochemical and biophysical research communications · 2007Article
- Current methods for detecting antibodies against erythropoietin and other recombinant proteins.Clinical and diagnostic laboratory immunology · 2005Review
- The influence of STAT5 antisense oligonucleotides on the proliferation and apoptosis of selected human leukaemic cell lines.Cell proliferation · 2003Article
- Article
- Review
- Control of myeloid differentiation and survival by Stats.Oncogene · 2000Review
- The role of STATs in myeloid differentiation and leukemia.Oncogene · 2000Review
- Dominant action of mutated erythropoietin receptors on differentiation in vitro and erythroleukemia development in vivo.Oncogene · 2000Article
- Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation.Genes & development · 2000Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TF-1 cell line has been established from a patient with erythroleukemia. While various cytokines induce TF-1 cell proliferation, erythropoietin (Epo) only sustains the short-term growth of these cells and induces their differentiation along the erythroid lineage. A truncated Epo receptor (EpoR) is overexpressed in these cells. The truncation removed the 96 C-terminal amino acids, including seven tyrosine residues. An additional single mutation at position +3 of Tyr344 led to the replacement of leucine 347 by proline. Stimulation by Epo induced an impaired activation of the STAT5 transcription factor in these cells. The same defect in STAT5 activation was found in the murine FDCP-1 cell line transfected with a chimeric EpoR containing the abnormal TF-1 EpoR cytoplasmic domain. Infection of TF-1 cells with a retrovirus containing a normal murine EpoR was able to restore both Epo-induced STAT5 activity and cellular proliferation. In contrast, Epo-induced differentiation was reduced strongly in infected TF-1ER cells. These results suggest that Epo-induced differentiation correlates with impaired Epo-induced STAT5 activation.
Indexed as
Identifiers
8861946PMC452141W1498439513What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.