ArticleEuropean journal of applied physiology and occupational physiology1996
Effect of physical exercise on adoptive experimental auto-immune encephalomyelitis in rats.
Article in European journal of applied physiology and occupational physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Endurance Exercise Attenuates Established Progressive Experimental Autoimmune Encephalomyelitis and Is Associated with an Amelioration of Innate Immune Responses in NOD Mice.International journal of molecular sciences · 2023Article
- Multiple sclerosis and exercise-A disease-modifying intervention of mice or men?Frontiers in neurology · 2023Review
- Effectiveness of exercise interventions in animal models of multiple sclerosis.Frontiers in medicine · 2023Review
- Exercise training alters autoimmune cell invasion into the brain in autoimmune encephalomyelitis.Annals of clinical and translational neurology · 2022Article
- Exercise intensity-dependent immunomodulatory effects on encephalomyelitis.Annals of clinical and translational neurology · 2019Article
- Immunomodulatory Effects of Exercise in Experimental Multiple Sclerosis.Frontiers in immunology · 2019Review
- On the Run for Hippocampal Plasticity.Cold Spring Harbor perspectives in medicine · 2018Review
- Regular Exercise Modifies Histopathological Outcomes of Pharmacological Treatment in Experimental Autoimmune Encephalomyelitis.Frontiers in neurology · 2018Article
- Comprehensive catwalk gait analysis in a chronic model of multiple sclerosis subjected to treadmill exercise training.BMC neurology · 2017Article
- Physical Exercise Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Peripheral Immune Response and Blood-Brain Barrier Disruption.Molecular neurobiology · 2017Article
- Exercise in the management of persons with multiple sclerosis.Therapeutic advances in neurological disorders · 2015Review
- Effects of exercise in experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis).Journal of neuroimmunology · 2014Review
- Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?Therapeutic advances in neurological disorders · 2012Article
- Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis.Brain research · 2010Article
- Exercise and brain health--implications for multiple sclerosis: Part 1--neuronal growth factors.Sports medicine (Auckland, N.Z.) · 2008Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to determine whether different programmes of exercise influence adoptive monophasic experimental auto-immune encephalomyelitis (adoptive EAE), a paralytic disease mediated by T-cells. Adoptive EAE was induced by the transfer of activated encephalitogenic T-lymphocytes into syngeneic recipients (Lewis rats, n = 85) and its development was followed by two independent observers. The results showed that 2 days of severe exercise (250 and 300 min) performed after the adoptive transfer of EAE slightly delayed the onset of the disease (P <0.008) and the day of its maximal severity (P <0.016) without affecting the overall severity of the disease. When this programme of exercise was performed before the cell transfer, it had no effect (P > 0.05). Two more moderate exercise programmes (5 x 120 min of running at constant speed or 5 x 60 min of running at variable speed, 5 consecutive days) performed between the adoptive transfer and the onset of the disease did not modify the development of the clinical signs of adoptive EAE (P >0.05). These results showed that severe exercise slightly influenced the effector phase of monophasic EAE and confirmed that physical exercise performed before the onset of experimental auto-immune diseases did not exacerbate the clinical signs.
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Registered trials
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