ReviewHistochemistry and cell biology1996
Applications of immunogold and lectin-gold labeling in tumor research and diagnosis.
Review in Histochemistry and cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Electron tomography and cryo-SEM characterization reveals novel ultrastructural features of host-parasite interaction during Chlamydia abortus infection.Histochemistry and cell biology · 2014Article
- Simultaneous detection of multiple targets for ultrastructural immunocytochemistry.Histochemistry and cell biology · 2014Article
- Immunogold cytochemistry in neuroscience.Nature neuroscience · 2013Article
- Preparation and high-resolution microscopy of gold cluster labeled nucleic acid conjugates and nanodevices.Micron (Oxford, England : 1993) · 2011Review
- Streamlined embedding of cell monolayers on gridded glass-bottom imaging dishes for correlative light and electron microscopy.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2010Article
- Quantitative assessment of specificity in immunoelectron microscopy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Differential expression of sialic acid on porcine organs during the maturation process.Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology · 2000Article
- The silver anniversary of gold: 25 years of the colloidal gold marker system for immunocytochemistry and histochemistry.Histochemistry and cell biology · 1996Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunohistochemistry and carbohydrate histochemistry have had an enormous impact on both tumor research and diagnosis. In particular, immunogold labeling has provided significant advantages over classical fluorescence and enzyme-based techniques. In light microscopy, the silver-intensified gold labeling has proven highly sensitive and precise in localization. In electron microscopy, the gold particle marker was a prerequisite for successful and unequivocal antigen detection in electron-dense cellular structures such as secretory granules. In this review we demonstrate the usefulness of light and electron microscopical gold labeling techniques as applied in tumor research and diagnosis. The examples include expression of beta-1,6 branches and specific sialoglycoconjugates in colon carcinoma, b-12 carbohydrate epitope in breast carcinoma, polysialic acid in neuroendocrine tumors of lung, adrenal and thyroid, as well as studies on proinsulin to insulin conversion in insulinomas. In addition, practical hints for prevention of background staining, tissue fixation, and silver intensification of gold labeling are given.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.