ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1996
Clinical and radiological presentation of 95 orbital lymphoid tumors.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 81 citations in OpenAlex.
- Value of MR imaging in the differentiation of benign and malignant orbital tumors in adults.European radiology · 2010Trial
- Characteristics of orbital lymphoproliferative disorders: a retrospective study of 84 cases.Eye (London, England) · 2025Article
- Deep learning-based intratumoral and peritumoral features for differentiating ocular adnexal lymphoma and idiopathic orbital inflammation.European radiology · 2025Article
- Radiotherapy of Orbital and Ocular Adnexa Lymphoma: Literature Review and University of Catania Experience.Cancers · 2023Review
- [Orbital T-cell lymphoma-Case presentation and review of the literature].Die Ophthalmologie · 2023Review
- The diagnostic value ofInternational ophthalmology · 2022Article
- Rare Diseases of the Orbit.Laryngo- rhino- otologie · 2021Review
- Morphologic Cross-Sectional Imaging Features of IgG4-Related Orbitopathy in Comparison to Ocular Adnexal Lymphoma.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- A Case of Compressive Optic Neuropathy Secondary to Lymphoma of the Extraocular Muscles.Neuro-ophthalmology (Aeolus Press) · 2019Article
- Ocular adnexal marginal zone lymphoma of mucosa-associated lymphoid tissue.Clinical and experimental medicine · 2018Review
- Characteristics of orbital lymphoma: a clinicopathological study of 26 cases.International ophthalmology · 2018Article
- [Lymphoma of the ocular adnexa].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2015Review
- Orbital lymphoma mimicking lacrimal gland pleomorphic adenoma.Case reports in ophthalmology · 2013Article
- A reappraisal of the diagnostic and therapeutic management of uncommon histologies of primary ocular adnexal lymphoma.The oncologist · 2013Review
- [Orbital neoplasia. Part II: mesenchymal, leukemic, lymphoproliferative and bony tumors, metastasis].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2013Article
- Conjunctival lymphoma arising from reactive lymphoid hyperplasia.World journal of surgical oncology · 2012Article
- [Clinical and neuroradiological diagnostics of orbital tumors].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2011Review
- CT and MRI findings with histopathologic correlation of a unique bilateral orbital mantle cell lymphoma in Graves' disease: a case report and brief review of literature.Journal of neuro-oncology · 2010Review
- Review
- [Diseases of the lacrimal gland].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough most orbital lymphoid tumors are characterized by a slow, painless onset and a mass that molds to orbital structures, different presentations may occur. Intensity on T2-weighted MRI is a possible means for differentiating lymphoid tumors (hyperintense) from pseudotumors (hypointense). In addition, it is generally assumed that 75% of orbital lymphomas are at stage I on presentation.
methodsThe clinical, CT, and MRI presentation of 95 primary and secondary orbital lymphoid tumors (63 non-Hodgkin lymphomas and 32 lymphoid hyperplasias) and their histological grade and staging were reviewed. Immunohistochemistry and PCR were used to determine clonality.
resultsNo significant differences were found between non-Hodgkin lymphomas and lymphoid hyperplasias, except for the mean age of the patients (6.3 years older in non-Hodgkin lymphomas). In both groups the most common presentation was a mass with an indolent course; visual impairment was seen in 13%, conjunctival redness in 25%, pain in 12%, and acute orbital inflammation in 15% of the patients. In most cases, the CT showed one or more lobulated or rounded masses, molding to adjacent structures, or a wedge-shaped enlargement of the lacrimal gland. Intramuscular lymphomas were rare and always associated with extramuscular masses. On T2-weighted MRI, only 35% of lymphoid tumors were hyperintense. Only 49% of lymphomas were at stage I on presentation.
conclusionAn inflammatory presentation is not uncommon in orbital lymphoid tumors. Shape, molding and multiple masses can help radiological diagnosis, whereas MRI T2 intensity is unreliable. Accurate staging can disclose systemic disease in more than 50% of cases of non-Hodgkin lymphoma.
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