ArticleThe Journal of cell biology1996
Intracellular signaling is changed after clustering of the neural cell adhesion molecules axonin-1 and NgCAM during neurite fasciculation.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- New Partners Identified by Mass Spectrometry Assay Reveal Functions of NCAM2 in Neural Cytoskeleton Organization.International journal of molecular sciences · 2021Article
- Contactin-2/TAG-1, active on the front line for three decades.Cell adhesion & migration · 2017Article
- Downregulation of L1 perturbs neuronal migration and alters the expression of transcription factors in murine neocortex.Journal of neuroscience research · 2013Article
- Cellular entry of lymphocytic choriomeningitis virus.Journal of virology · 2008Article
- Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell.Molecular biology of the cell · 2007Article
- Migration of nerve growth cones requires detergent-resistant membranes in a spatially defined and substrate-dependent manner.The Journal of cell biology · 2002Article
- L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1.The Journal of cell biology · 2002Article
- Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity.The Journal of cell biology · 2001Article
- Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2.Molecular biology of the cell · 2001Article
- Defining a role and mechanism for IgCAM function in vertebrate axon guidance.The Journal of cell biology · 2000Article
- A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons.The Journal of cell biology · 2000Article
- Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn.The Journal of cell biology · 1999Article
- Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Ethanol inhibits L1-mediated neurite outgrowth in postnatal rat cerebellar granule cells.The Journal of biological chemistry · 1999Article
- Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes.Molecular biology of the cell · 1999Article
- Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule.The Journal of cell biology · 1998Article
- Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells.The Journal of cell biology · 1998Article
- The role of glycoproteins in neural development function, and disease.Molecular neurobiology · 1998Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural cell adhesion molecules of the immunoglobulin/fibronectin type III family on axons have been implicated in promotion of neurite outgrowth, fasciculation, and the mediation of specific cell adhesion. The present study demonstrates that two of these molecules on dorsal root ganglion neurons are associated with distinct protein kinases, axonin-1 with the src-related nonreceptor tyrosine kinase fyn and NgCAM with a casein kinase II-related activity and a serine/ threonine kinase related to S6 kinase. When neurites grew without contacts involving axonin-1 and NgCAM, strong fyn kinase activity was associated with axonin-1, whereas the NgCAM-associated kinase activities were low. Clustering of axonin-1 with NgCAM induced by the formation of cell-cell contacts correlated with a reduction of the axonin-1-associated fyn activity and an increased phosphorylation of NgCAM by the associated casein kinase II-related activity. Thus, axonin-1 and NgCAM trigger distinctive intracellular signals during in vitro differentiation depending on their state of association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.