ArticleThe Journal of cell biology1996
Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 111 citations in OpenAlex.
- Integrative gene duplication and genome-wide analysis characterize Peroxin11 gene family in wheat.BMC genomics · 2026Article
- Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts.Molecular biology and evolution · 2026Article
- Molecular basis of the glycosomal targeting of PEX11 and its mislocalization to mitochondrion in trypanosomes.Frontiers in cell and developmental biology · 2023Article
- How to improve the production of peptidyl compounds in filamentous fungi.Frontiers in fungal biology · 2022Article
- Methods to Analyze the Redox Reactivity of Plant Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Many Faces of Amphipathic Helices.Biomolecules · 2018Review
- Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.Physiological reviews · 2018Review
- Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis.The Journal of biological chemistry · 2017Article
- Pro- and Antioxidant Functions of the Peroxisome-Mitochondria Connection and Its Impact on Aging and Disease.Oxidative medicine and cellular longevity · 2017Review
- Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.The Journal of biological chemistry · 2016Article
- Giant peroxisomes in a moss (Physcomitrella patens) peroxisomal biogenesis factor 11 mutant.The New phytologist · 2016Article
- Genome-Wide Localization Study of Yeast Pex11 Identifies Peroxisome-Mitochondria Interactions through the ERMES Complex.Journal of molecular biology · 2015Article
- Role of Pex11p in Lipid Homeostasis in Yarrowia lipolytica.Eukaryotic cell · 2015Article
- Redox regulated peroxisome homeostasis.Redox biology · 2015Review
- Peroxisomes take shape.Nature reviews. Molecular cell biology · 2013Review
- Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.The Journal of biological chemistry · 2013Article
- Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- Phosphorylation-dependent Pex11p and Fis1p interaction regulates peroxisome division.Molecular biology of the cell · 2012Article
- A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomes.Traffic (Copenhagen, Denmark) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Pex11p (formerly Pmp27) has been implicated in peroxisomal proliferation (Erdmann, R., and G. Blobel. 1995. J. Cell Biol. 128; 509-523; Marshall, P.A., Y.I. Krimkevich, R.H. Lark, J.M. Dyer, M. Veenhuis, and J.M. Goodman, 1995. J. Cell Biol. 129; 345-355). In its absence, peroxisomes in Saccharomyces cerevisiae fail to proliferate in response to oleic acid; instead, one or two large peroxisomes are formed. Conversely, overproduction of Pex11p causes an increase in peroxisomal number. In this report, we confirm the function of Pex11p in organelle proliferation by demonstrating that this protein can cause fragmentation in vivo of large peroxisomes into smaller organelles. Pex11p is on the inner surface of the peroxisomal membrane. It can form homodimers, and this species is more abundant in mature peroxisomes than in proliferating organelles. Removing one of the three cysteines in the protein inhibits homodimerization. This cysteine 3-->alanine mutation leads to an increase in number and a decrease in peroxisomal density, compared with the wild-type protein, in response to oleic acid. We propose that the active species is the "monomeric" form, and that the increasing oxidative metabolism within maturing peroxisomes causes dimer formation and inhibition of further organelle division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.