Evidence map›Paper›PMID 8858167›Full record

ArticleThe Journal of cell biology1996

Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor.

R Erdmann, G Blobel

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 220 citations in OpenAlex.

  1. Review
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  8. Review
  9. Article
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  12. Article
  13. Peroxisome protein import recapitulated inThe Journal of cell biology · 2019
    Article
  14. Review
  15. Article
  16. Article
  17. Peroxisome biogenesis disorders.Translational science of rare diseases · 2016
    Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R ErdmannLaboratory of Cell Biology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA. Erdmann@rzruhr-uni-bochum.de
G Blobel
Howard Hughes Medical Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have identified an S. cerevisiae integral peroxisomal membrane protein of M of 42,705 (Pex13p) that is a component of the peroxisomal protein import apparatus. Pex13p's most striking feature is an src homology 3 (SH3) domain that interacts directly with yeast Pex5p (former Pas10p), the recognition factor for the COOH-terminal tripeptide signal sequence (PTS1), but not with Pex7p (former Pas7p), the recognition factor for the NH2-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins. Hence, Pex13p serves as peroxisomal membrane receptor for at least one of the two peroxisomal signal recognition factors. Cells deficient in Pex13p are unable to import peroxisomal matrix proteins containing PTS1 and, surprisingly, also those containing PTS2. Pex13p deficient cells retain membranes containing the peroxisomal membrane protein Pex11p (former Pmp27p), consistent with the existence of independent pathways for the integration of peroxisomal membrane proteins and for the translocation of peroxisomal matrix proteins.

Indexed as

Saccharomyces cerevisiae ProteinsAcetyl-CoA C-AcetyltransferaseAmino Acid SequenceBiological TransportCatalaseCloning, MolecularFumarate HydrataseFungal ProteinsGenes, FungalIntracellular MembranesMembrane ProteinsMicrobodiesMolecular Sequence DataOleic AcidPeroxinsPeroxisomal Targeting Signal 2 ReceptorAcetyl-CoA C-AcetyltransferaseCatalaseFumarate HydrataseFungal ProteinsMembrane ProteinsOleic AcidPeroxinsPeroxisomal Targeting Signal 2 ReceptorPeroxisome-Targeting Signal 1 ReceptorPEX11A protein, humanPEX11B protein, humanPEX11 protein, S cerevisiaePEX13 protein, S cerevisiaeReceptors, Cytoplasmic and NuclearRecombinant Fusion ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID8858167
PMCPMC2121012
OpenAlexW1998394653

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.