ArticleMolecular biology of the cell1996
Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells.
Article in Molecular biology of the cell, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 113 citations in OpenAlex.
- Blockade of FGFR1 Trafficking to the Cell Surface Results in the Partial Mistargeting of the Receptor to Peroxisomes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Metabotropic Glutamate Receptor 3 Expression During Liver Disease Progression: Association with Inflammation and Cell Viability in Hepatocellular Carcinoma.International journal of molecular sciences · 2026Article
- Systems Genome: Coordinated Gene Activity Networks, Recurring Coordination Modules, and Genome Homeostasis in Developing Neurons.International journal of molecular sciences · 2024Article
- Article
- Global Genome Conformational Programming during Neuronal Development Is Associated with CTCF and Nuclear FGFR1-The Genome Archipelago Model.International journal of molecular sciences · 2020Article
- Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation.Cells · 2019Article
- PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.The Journal of cell biology · 2018Article
- Retrograde trafficking of β-dystroglycan from the plasma membrane to the nucleus.Scientific reports · 2017Article
- Common developmental genome deprogramming in schizophrenia - Role of Integrative Nuclear FGFR1 Signaling (INFS).Schizophrenia research · 2017Article
- Global Developmental Gene Programing Involves a Nuclear Form of Fibroblast Growth Factor Receptor-1 (FGFR1).PloS one · 2015Article
- Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2014Article
- Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.EMBO molecular medicine · 2014Article
- Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by α7 nicotinic receptor agonist.Stem cells translational medicine · 2013Article
- Biological function of nuclear receptor tyrosine kinase action.Cold Spring Harbor perspectives in biology · 2013Review
- NGF-induced cell differentiation and gene activation is mediated by integrative nuclear FGFR1 signaling (INFS).PloS one · 2013Article
- Nuclear localization of Klotho in brain: an anti-aging protein.Neurobiology of aging · 2012Article
- FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.The Journal of cell biology · 2012Article
- Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons.The Journal of biological chemistry · 2012Article
- Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis.Schizophrenia research · 2009Article
- Ultraviolet irradiation-induces epidermal growth factor receptor (EGFR) nuclear translocation in human keratinocytes.Journal of cellular biochemistry · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In an effort to determine the localization of fibroblast growth factor (FGF) receptors (FGFR) that could mediate the intracellular action of FGF-2, we discovered the presence of high-affinity. FGF-2 binding sites in the nuclei of bovine adrenal medullary cells (BAMC). Western blot analysis demonstrated the presence of 103-, 118-, and 145-kDa forms of FGFR1 in nuclei isolated from BAMC. 125I-FGF-2 cross-linking to nuclear extracts followed by FGFR1 immunoprecipitation showed that FGFR1 can account for the nuclear FGF-2 binding sites. Nuclear FGFR1 has kinase activity and undergoes autophosphorylation. Immunocytochemistry with the use of confocal and electron microscopes demonstrated the presence of FGFR1 within the nuclear interior. Nuclear subfractionation followed by Western blot or immunoelectron microscopic analysis showed that the nuclear FGFR1 is contained in the nuclear matrix and the nucleoplasm. Agents that induce translocation of endogenous FGF-2 to the nucleus (forskolin, carbachol, or angiotensin II) increased the intranuclear accumulation of FGFR1. This accumulation was accompanied by an overall increase in FGF-2-inducible tyrosine kinase activity. Our findings suggest a novel mode for growth factor action whereby growth factor receptors translocate to the nucleus in parallel with their ligand and act as direct mediators of nuclear responses to cell stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.