ArticleBritish journal of cancer1996
Nm23 expression in endometrial and cervical cancer: inverse correlation with lymph node involvement and myometrial invasion.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mechanisms of non-metastatic 2 (NME2)-mediated control of metastasis across tumor types.Naunyn-Schmiedeberg's archives of pharmacology · 2011Pooled it
- LINC00636 promotes lymph node metastasis and cervical cancer through targeting NM23.Bioscience reports · 2020Observational
- GOG 8020/210: Risk stratification of lymph node metastasis, disease progression and survival using single nucleotide polymorphisms in endometrial cancer: An NRG oncology/gynecologic oncology group study.Gynecologic oncology · 2019Article
- NDPKA is not just a metastasis suppressor - be aware of its metastasis-promoting role in neuroblastoma.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Regulatory functions of Nm23-H2 in tumorigenesis: insights from biochemical to clinical perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2015Review
- NME2 reduces proliferation, migration and invasion of gastric cancer cells to limit metastasis.PloS one · 2015Article
- Engineered reversal of drug resistance in cancer cells--metastases suppressor factors as change agents.Nucleic acids research · 2014Article
- Down-regulated nucleoside diphosphate kinase nm23-H1 expression is unrelated to high-risk human papillomavirus but associated with progression of cervical intraepithelial neoplasia and unfavourable prognosis in cervical cancer.Journal of clinical pathology · 2006Article
- Clinical significance of nm23 expression and chromosome 17 numerical aberrations in primary gastric cancer.Medical oncology (Northwood, London, England) · 2002Article
- KAI1 metastasis suppressor gene is frequently down-regulated in cervical carcinoma.The American journal of pathology · 2001Article
- The predictive value of vascular endothelial growth factor and nm23 for the diagnosis of occult metastasis in non-small cell lung cancer.Japanese journal of cancer research : Gann · 2001Article
- Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival.BMC cancer · 2001Article
- Modulation of the basal activity of phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells.Glycoconjugate journal · 2000Article
- Molecular biology of breast cancer metastasis. Genetic regulation of human breast carcinoma metastasis.Breast cancer research : BCR · 2000Review
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8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of nm23 has been shown to correlate in some solid tumours with their metastatic potential and to be associated with a favourable prognosis in human breast cancer and melanoma. In breast and ovarian cancer nm23 expression is also correlated with lymph node involvement. We analysed the expression of nm23-H1 and -H2 in normal endometrium and in endometrial and cervical cancer by both Northern and Western blotting. Cellular localisation of Nm23-H1 was visualised by immunohistochemistry mostly in the cytoplasm. Both isoforms of Nm23 were present in all the samples analysed, and a clear direct correlation between Nm23-H1 and -H2 levels was evident. Median nm23-H2 levels were higher than than -H1 levels in both tissues. Cervical cancer patients with lymph node involvement were shown to have significantly lower protein levels of Nm23 (P < 0.007 for H1 and P < 0.009 for H2), and a similar trend was also evident in endometrial cancer. Furthermore, the degree of myometrial invasion in endometrial cancer patients was also inversely correlated with Nm23-H1 levels of expression (P < 0.003). Nm23 level may therefore be taken into consideration as a new marker in the prognostic characterisation and in the treatment planning of uterine tumour patients.
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