ArticleProceedings of the National Academy of Sciences of the United States of America1996
A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 156 citations in OpenAlex.
- Diacylglycerol kinase is a keystone regulator of signaling relevant to the pathophysiology of asthma.American journal of physiology. Lung cellular and molecular physiology · 2024Review
- Diacylglycerol kinase ζ interacts with sphingomyelin synthase 1 and sphingomyelin synthase-related protein via different regions.FEBS open bio · 2023Article
- Discrete localization of phospholipase Cβ3 and diacylglycerol kinase ι along the renal proximal tubules of normal rat kidney and gentamicin-induced changes in their expression.Histochemistry and cell biology · 2023Article
- The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy.Molecules (Basel, Switzerland) · 2022Review
- The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function.Autoimmunity reviews · 2021Review
- New Era of Diacylglycerol Kinase, Phosphatidic Acid and Phosphatidic Acid-Binding Protein.International journal of molecular sciences · 2020Review
- Increase in PKCα Activity during Heart Failure Despite the Stimulation of PKCα Braking Mechanism.International journal of molecular sciences · 2020Article
- Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes.Cells · 2020Review
- Expression and localization of diacylglycerol kinase ζ in guinea pig cochlea and its functional implication under noise-exposure stress conditions.Histochemistry and cell biology · 2019Article
- Diacylglycerol kinase ζ is a negative regulator of GPVI-mediated platelet activation.Blood advances · 2019Article
- Article
- DGKζ deficiency protects against peripheral insulin resistance and improves energy metabolism.Journal of lipid research · 2017Article
- The Ligand Binding Landscape of Diacylglycerol Kinases.Cell chemical biology · 2017Article
- A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes.Scientific reports · 2016Article
- The Immunomodulatory Functions of Diacylglycerol Kinase ζ.Frontiers in cell and developmental biology · 2016Review
- Arachidonoyl-Specific Diacylglycerol Kinase ε and the Endoplasmic Reticulum.Frontiers in cell and developmental biology · 2016Review
- Diacylglycerol Kinases as Emerging Potential Drug Targets for a Variety of Diseases: An Update.Frontiers in cell and developmental biology · 2016Review
- Selective localization of diacylglycerol kinase (DGK)ζ in the terminal tubule cells in the submandibular glands of early postnatal mice.Histochemistry and cell biology · 2015Article
- Expression and localization of type II diacylglycerol kinase isozymes δ and η in the developing mouse brain.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
- Diacylglycerol kinase as a possible therapeutic target for neuronal diseases.Journal of biomedical science · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cDNA corresponding to a fourth species of diacylglycerol (DG) kinase (EC 2.7.1.107) was isolated from cDNA libraries of rat retina and brain. This cDNA encoded a 929-aa, 104-kDa polypeptide termed DGK-IV. DGK-IV was different from previously identified mammalian DG kinase species, DGK-I, DGK-II, and DGK-III, in that it contained no EF-hand motifs but did contain four ankyrin-like repeats at the carboxyl terminus. These structural features of DGK-IV closely resemble the recently cloned, eye-specific DG kinase of Drosophila that is encoded by the retinal degeneration A (rdgA) gene. However, DGK-IV was expressed primarily in the thymus and brain with relatively low expression in the eye and intestine. Furthermore, the primary structure of the DGK-IV included a nuclear targeting motif, and immunocytochemical analysis revealed DGK-IV to localize in the nucleus of COS-7 cells transfected with the epitope-tagged cDNA, suggesting an involvement of DGK-IV in intranuclear processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.