ArticleProceedings of the National Academy of Sciences of the United States of America1996
Essential requirement of an invariant V alpha 14 T cell antigen receptor expression in the development of natural killer T cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 101 citations in OpenAlex.
- The effect of radiotherapy on NKT cells in patients with advanced head and neck cancer.Cancer immunology, immunotherapy : CII · 2010Trial
- Single-cell transcriptome analysis of medaka lymphocytes reveals absence of fully mature T cells in the thymus and the T-lineage commitment in the kidney.Frontiers in immunology · 2024Article
- Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells.Nature communications · 2023Article
- Sialokinin in mosquito saliva shifts human immune responses towards intracellular pathogens.PLoS neglected tropical diseases · 2023Article
- Identification of a PD-L1+Tim-1+ iNKT subset that protects against fine particulate matter-induced airway inflammation.JCI insight · 2022Article
- Mosquito-bite infection of humanized mice with chikungunya virus produces systemic disease with long-term effects.PLoS neglected tropical diseases · 2021Article
- Complementary approaches to study NKT cells in cancer.Methods in enzymology · 2020Article
- Regulatory T cells induce CD4Cancer immunology, immunotherapy : CII · 2019Article
- T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells.Frontiers in immunology · 2019Review
- Mosquito saliva alone has profound effects on the human immune system.PLoS neglected tropical diseases · 2018Article
- Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells.Frontiers in immunology · 2018Review
- Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- TIM-4 is expressed on invariant NKT cells but dispensable for their development and function.Oncotarget · 2016Article
- Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer.Cancer science · 2016Article
- Genetic engineering of hematopoietic stem cells to generate invariant natural killer T cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Antitumor Responses of Invariant Natural Killer T Cells.Journal of immunology research · 2015Review
- Orchestration of invariant natural killer T cell development by E and Id proteins.Critical reviews in immunology · 2015Review
- Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature NKT cell.International immunology · 2014Article
- Ex vivo purification and characterization of human invariant Natural Killer T cells.Journal of immunological methods · 2011Review
- Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis.Hepatology (Baltimore, Md.) · 2010Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
NK1.1+ T [natural killer (NK) T] cells express an invariant T cell antigen receptor alpha chain (TCR alpha) encoded by V alpha 14 and J alpha 281 segments in association with a limited number of V betas, predominantly V beta 8.2. Expression of the invariant V alpha 14/J alpha 281, but not V alpha 1, TCR in transgenic mice lacking endogenous TCR alpha expression blocks the development of conventional T alpha beta cells and leads to the preferential development of V alpha 14 NK T cells, suggesting a prerequisite role of invariant V alpha 14 TCR in NK T cell development. In V beta 8.2 but not B beta 3 transgenic mice, two NK T cells with different CD3 epsilon expressions, CD3 epsilon(dim) and CD3 epsilon(high), can be identified. CD3 epsilon(high) NK T cells express surface V alpha 14/V beta 8 TCR, indicating a mature cell type, whereas CD3 epsilon(dim) NK T cells express V beta 8 without V alpha 14 TCR and no significant CD3 epsilon expression (CD3 epsilon(dim)) on the cell surface. However, the latter are positive for recombination activating gene (RAG-1 and RAG-2) mRNA, which are only expressed in the precursor or immature T cell lineage, and also possess CD3 epsilon mRNA in their cytoplasm, suggesting that CD3 epsilon(dim) NK T cells are the precursor of V alpha 14 NK T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.