ArticleProceedings of the National Academy of Sciences of the United States of America1996
Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 187 citations in OpenAlex.
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- Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate.The Korean journal of parasitology · 2019Article
- Glycoconjugates of Gram-negative bacteria and parasitic protozoa - are they similar in orchestrating the innate immune response?Innate immunity · 2019Review
- Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner.PLoS neglected tropical diseases · 2018Article
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- Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis.International journal of nanomedicine · 2017Article
- Supplementation of host response by targeting nitric oxide to the macrophage cytosol is efficacious in the hamster model of visceral leishmaniasis and adds to efficacy of amphotericin B.International journal for parasitology. Drugs and drug resistance · 2016Article
- Lipophosphoglycans from Leishmania amazonensis Strains Display Immunomodulatory Properties via TLR4 and Do Not Affect Sand Fly Infection.PLoS neglected tropical diseases · 2016Article
- The genetics of Leishmania virulence.Medical microbiology and immunology · 2015Review
- Characterization of a ricin-resistant mutant of Leishmania donovani that expresses lipophosphoglycan.Glycobiology · 2015Article
- Leishmania enriettii: biochemical characterisation of lipophosphoglycans (LPGs) and glycoinositolphospholipids (GIPLs) and infectivity to Cavia porcellus.Parasites & vectors · 2015Article
- Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.The Journal of clinical investigation · 2014Article
- Deception and manipulation: the arms of leishmania, a successful parasite.Frontiers in immunology · 2014Review
- Two biochemically distinct lipophosphoglycans from Leishmania braziliensis and Leishmania infantum trigger different innate immune responses in murine macrophages.Parasites & vectors · 2013Article
- Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of α-galactosyl residues.The American journal of tropical medicine and hygiene · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Lipophosphoglycan (LPG) glycoconjugates from promastigotes of Leishmania were not able to induce the expression of the cytokine-inducible nitric oxide synthase (iNOS) by the murine macrophage cell line, J774. However, they synergize with interferon gamma to stimulate the macrophages to express high levels of iNOS. This synergistic effect was critically time-dependent. Preincubation of J774 cells with the LPG glycans 4-18 h before stimulation with interferon gamma resulted in a significant reduction in the expression of iNOS mRNA and of NO synthesis, compared with cells preincubated with culture medium alone. The regulatory effect on the induction of iNOS by LPG is located in the LPG phosphoglycan disaccharide backbone. Synthetic fragments of this backbone had a similar regulatory effect on NO synthesis. Further, the production of NO by activated macrophages in the present system was correlated directly with the leishmanicidal capacity of the cells. These data therefore demonstrate that LPG glycoconjugates have a profound effect on the survival of Leishmania parasites through their ability to regulate the expression of iNOS by macrophages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.