ArticleProceedings of the National Academy of Sciences of the United States of America1996
A novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 54 citations in OpenAlex.
- Where do obesity and male infertility collide?BMC medical genomics · 2024Article
- Early-adulthood spike in protein translation drives aging via juvenile hormone/germline signaling.Nature communications · 2023Article
- Review
- Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.Zebrafish · 2016Article
- Sterols in spermatogenesis and sperm maturation.Journal of lipid research · 2013Review
- Integrated lipidomics in the secreted phospholipase A(2) biology.International journal of molecular sciences · 2011Review
- Epididymis cholesterol homeostasis and sperm fertilizing ability.Asian journal of andrology · 2011Review
- Mendelian genetics of male infertility.Annals of the New York Academy of Sciences · 2010Review
- Human luteinized granulosa cells secrete apoB100-containing lipoproteins.Journal of lipid research · 2010Article
- Group III secreted phospholipase A2 regulates epididymal sperm maturation and fertility in mice.The Journal of clinical investigation · 2010Article
- Posttesticular sperm maturation, infertility, and hypercholesterolemia.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Male infertility, affecting as many as 10% of the adult population, is an extremely prevalent disorder. In most cases, the cause of the condition is unknown, and genetic factors that might affect male fertility, other than some sequences on the Y chromosome, have not been identified. We report here that male mice heterozygous for a targeted mutation of the apolipoprotein B (apo B) gene exhibit severely compromised fertility. Sperm from these mice failed to fertilize eggs both in vivo and in vitro. However, these sperm were able to fertilize eggs once the zona pellucida was removed but displayed persistent abnormal binding to the egg after fertilization. In vitro fertilization-related and other experiments revealed reduced sperm motility, survival time, and sperm count also contributed to the infertility phenotype. Recognition of the infertility phenotype led to the identification of apo B mRNA in the testes and epididymides of normal mice, and these transcripts were substantially reduced in the affected animals. Moreover, when the genomic sequence encoding human apo B was introduced into these animals, normal fertility was restored. These findings suggest that this genetic locus may have an important impact on male fertility and identify a previously unrecognized function for apo B.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.