ArticleProceedings of the National Academy of Sciences of the United States of America1996
Moderate increase in histone acetylation activates the mouse mammary tumor virus promoter and remodels its nucleosome structure.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 97 citations in OpenAlex.
- The contributions of DNA accessibility and transcription factor occupancy to enhancer activity during cellular differentiation.G3 (Bethesda, Md.) · 2024Article
- Minireview: The versatile roles of lysine deacetylases in steroid receptor signaling.Molecular endocrinology (Baltimore, Md.) · 2014Review
- Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells.Cell death & disease · 2013Article
- Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.Genes & development · 2011Article
- The WNKs: atypical protein kinases with pleiotropic actions.Physiological reviews · 2011Review
- HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.Journal of biomedicine & biotechnology · 2011Article
- Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin.Molecular endocrinology (Baltimore, Md.) · 2010Review
- Erk signaling and chromatin remodeling in MMTV promoter activation by progestins.Nuclear receptor signaling · 2009Review
- Two chromatin remodeling activities cooperate during activation of hormone responsive promoters.PLoS genetics · 2009Article
- Histone acetylation-independent transcription stimulation by a histone chaperone.Nucleic acids research · 2007Article
- Nature of the accessible chromatin at a glucocorticoid-responsive enhancer.Molecular and cellular biology · 2004Article
- Interaction of maize Opaque-2 and the transcriptional co-activators GCN5 and ADA2, in the modulation of transcriptional activity.Plant molecular biology · 2004Article
- Article
- Chromatin remodeling by nuclear receptors.Chromosoma · 2003Review
- Fragile X (CGG)n repeats induce a transcriptional repression in cis upon a linked promoter: evidence for a chromatin mediated effect.BMC molecular biology · 2003Article
- Nuclear microenvironments support physiological control of gene expression.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003Review
- Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium.Molecular and cellular biology · 2002Article
- Chromosomal integration of retinoic acid response elements prevents cooperative transcriptional activation by retinoic acid receptor and retinoid X receptor.Molecular and cellular biology · 2002Article
- Chromatin remodeling and transcriptional activation: the cast (in order of appearance).Oncogene · 2001Review
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse mammary tumor virus (MMTV) promoter is regulated by steroid hormones through a hormone-responsive region that is organized in a positioned nucleosome. Hormone induction leads to a structural change of this nucleosome which makes its DNA more sensitive to cleavage by DNase I and enables simultaneous binding of all relevant transcription factors. In cells carrying either episomal or chromosomally integrated MMTV promoters, moderate acetylation of core histones, generated by treatment with low concentrations of the histone deacetylase inhibitors sodium butyrate or trichostatin A, enhances transcription from the MMTV promoter in the absence of hormone and potentiates transactivation by either glucocorticoids or progestins. At higher concentrations, histone deacetylase inhibitors reduce basal and hormone induced MMTV transcription. Inducing inhibitor concentrations lead to the same type of nucleosomal DNase I hypersensitivity as hormone treatment, suggesting that moderate acetylation of core histone activates the MMTV promoter by mechanisms involving chromatin remodeling similar to that generated by the inducing hormones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.