ArticleProceedings of the National Academy of Sciences of the United States of America1996
YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 80 citations in OpenAlex.
- YY1 in prostate cancer: multidimensional oncogenicmechanisms and emerging therapeutic vulnerabilities.Journal of molecular histology · 2026Review
- A Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells.Biology · 2022Article
- YY1 regulated transcription-based stratification of gastric tumors and identification of potential therapeutic candidates.Journal of cell communication and signaling · 2021Article
- Plasma Membrane Calcium ATPase Regulates Stoichiometry of CD4Frontiers in immunology · 2021Article
- Zinc-finger protein YY1 suppresses tumor growth of human nasopharyngeal carcinoma by inactivating c-Myc-mediatedThe Journal of biological chemistry · 2019Article
- The Two Sides of YY1 in Cancer: A Friend and a Foe.Frontiers in oncology · 2019Review
- Review
- Methylation of transcription factor YY2 regulates its transcriptional activity and cell proliferation.Cell discovery · 2017Article
- YY1 regulates melanoma tumorigenesis through a miR-9 ~ RYBP axis.Journal of experimental & clinical cancer research : CR · 2015Article
- MYC and mitochondrial biogenesis.Cold Spring Harbor perspectives in medicine · 2014Review
- Cellular MYCro economics: Balancing MYC function with MYC expression.Cold Spring Harbor perspectives in medicine · 2013Review
- Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.Nucleic acids research · 2012Article
- Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.Molecular and cellular biology · 2012Article
- YY1 regulates melanocyte development and function by cooperating with MITF.PLoS genetics · 2012Article
- The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle.PloS one · 2012Article
- Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters.Cell cycle (Georgetown, Tex.) · 2011Article
- The transcription factor YY1 is a substrate for Polo-like kinase 1 at the G2/M transition of the cell cycle.PloS one · 2011Article
- The oncogenic role of Yin Yang 1.Critical reviews in oncogenesis · 2011Review
- Genome-wide analysis of YY2 versus YY1 target genes.Nucleic acids research · 2010Article
- Regulation of the transcription factor YY1 in mitosis through phosphorylation of its DNA-binding domain.Molecular biology of the cell · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-Myc oncoprotein has previously been shown to associate with transcription regulator YY1 and to inhibit its activity. We show herein that endogenous c-Myc and YY1 associate in vivo and that changes in c-Myc levels, which accompany mitogenic stimulation or differentiation of cultured cells, affect the ratio of free to c-Myc-associated YY1. We have also investigated the mechanism by which association with c-Myc inhibits YY1's ability to regulate transcription. c-Myc does not block binding of YY1 to DNA. However, protein association studies suggest that c-Myc interferes with the ability of YY1 to contact basal transcription proteins TATA-binding protein and TFIIB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.