Evidence map›Paper›PMID 8855227›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America1996

Parallel human genome analysis: microarray-based expression monitoring of 1000 genes.

M Schena, D Shalon, R Heller, A Chai, P O Brown, R W Davis

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers.

0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

300 citing papers in PubMed.

  1. Trial
  2. Microarrays and the Dawn of Omics Data Analysis.Advances in experimental medicine and biology · 2026
    Review
  3. Neuregulin 2 Is a Candidate Gene for Autism Spectrum Disorder.International journal of molecular sciences · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Progress in Methods for Copy Number Variation Profiling.International journal of molecular sciences · 2022
    Review
  8. The transcriptomic revolution and radiation biology.International journal of radiation biology · 2022
    Article
  9. Review
  10. Highly Accurate Chip-Based Resequencing of SARS-CoV-2 Clinical Samples.Langmuir : the ACS journal of surfaces and colloids · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

240 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M SchenaDepartment of Biochemistry, Beckman Center, Stanford University Medical Center, CA 94305, USA. schena@cmgm.stanford.edu
D Shalon
R Heller
A Chai
P O Brown
R W Davis

Funding

EFFICIENT GENE MAPPING BY WHOLE GENOME MISMATCH SCANNINGR21HG000450 · NHGRI · STANFORD UNIVERSITY · PI BROWN, PATRICK O. · 1991 to 1993
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TECH DEVELOPMENT IN SUPPORT OF MAP AND SEQR37HG000198 · NHGRI · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE · 1990 to 1997
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NHGRI NIH HHS 3R21HG00450NHGRI NIH HHS R37HG00198
6 · The paper itself

Abstract

Microarrays containing 1046 human cDNAs of unknown sequence were printed on glass with high-speed robotics. These 1.0-cm2 DNA "chips" were used to quantitatively monitor differential expression of the cognate human genes using a highly sensitive two-color hybridization assay. Array elements that displayed differential expression patterns under given experimental conditions were characterized by sequencing. The identification of known and novel heat shock and phorbol ester-regulated genes in human T cells demonstrates the sensitivity of the assay. Parallel gene analysis with microarrays provides a rapid and efficient method for large-scale human gene discovery.

Indexed as

Gene ExpressionGene LibraryHeat-Shock ResponseCells, CulturedDNA, ComplementaryHumansMicrochemistryNucleic Acid HybridizationRNA, MessengerTetradecanoylphorbol AcetateT-LymphocytesDNA, ComplementaryRNA, MessengerTetradecanoylphorbol Acetate

Identifiers

PMID8855227
PMCPMC38202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.