ArticleGenetics1996
Molecular basis of the pleiotropic phenotype of mice carrying the hypervariable yellow (Ahvy) mutation at the agouti locus.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 79 citations in OpenAlex.
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- Small but sturdy: small RNAs in cellular memory and epigenetics.Genes & development · 2014Review
- The use of mouse models to study epigenetics.Cold Spring Harbor perspectives in biology · 2013Review
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- Animal evolution during domestication: the domesticated fox as a model.BioEssays : news and reviews in molecular, cellular and developmental biology · 2009Article
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- Genome-wide prediction of imprinted murine genes.Genome research · 2005Article
- Retrotransposon-derived elements in the mammalian genome: a potential source of disease.Journal of inherited metabolic disease · 2004Review
- Complex patterns of transcription at the insertion site of a retrotransposon in the mouse.Nucleic acids research · 2004Article
- Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
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- Induced instability of two Arabidopsis constitutive pathogen-response alleles.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity.Nucleic acids research · 2001Article
- Tumoral environment triggers transcript anomalies in established tumors: induction of altered gene expression and of aberrant, truncated and B2 repeat-containing gene transcripts.Neoplasia (New York, N.Y.) · 1999Article
- Intracisternal A-particle element transposition into the murine beta-glucuronidase gene correlates with loss of enzyme activity: a new model for beta-glucuronidase deficiency in the C3H mouse.Molecular and cellular biology · 1998Article
- The mouse pale ear (ep) mutation is the homologue of human Hermansky-Pudlak syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The murine agouti locus regulates a switch in pigment synthesis between eumelanin (black/brown pigment) and phaeomelanin (yellow/red pigment) by hair bulb melanocytes. We recently described a spontaneous mutation, hypervariable yellow (Ahvy) and demonstrated that Ahvy is responsible for the largest range of phenotypes yet identified at the agouti locus, producing mice that are obese with yellow coats to mice that are of normal weight with black coats. Here, we show that agouti expression is altered both temporally and spatially in Ahvy mutants. Agouti expression levels are positively correlated with the degree of yellow pigmentation in individual Ahvy mice, consistent with results from other dominant yellow agouti mutations. Sequencing of 5' RACE and genomic PCR products revealed that Ahvy resulted from the integration of an intracisternal A particle (IAP) in an antisense orientation within the 5' untranslated agouti exon 1C. This retrovirus-like element is responsible for deregulating agouti expression in Ahvy mice; agouti expression is correlated with the methylation state of CpG residues in the IAP long terminal repeat as well as in host genomic DNA. In addition, the data suggest that the variable phenotype of Ahvy offspring is influenced in part by the phenotype of their Ahvy female parent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.