ArticleInfection
Bactericidal effect of sparfloxacin alone and in combination with amoxicillin against Streptococcus pneumoniae as determined by kill-kinetic studies.
Article in Infection. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ten clinical isolates of Streptococcus pneumoniae (six intermediately penicillin-sensitive, one penicillin-resistant and three penicillin-sensitive strains) were studied by kill-kinetic experiments using sparfloxacin alone and in combination with amoxicillin. Equipotent doses of the antibiotics (1x, 2x and 4x the MIC) were used in the kill-kinetic studies. Sparfloxacin had a moderate bactericidal potential at 4x MIC after 5h and the combination with amoxicillin did not significantly increase its bactericidal activity. The clinical significance of these findings warrants further studies in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.