ArticleAnatomy and embryology1996
Chondrocytes synthesize type I collagen and accumulate the protein in the matrix during development of rat tibial articular cartilage.
Article in Anatomy and embryology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- Distribution of Immunomodulation, Protection and Regeneration Factors in Cleft-Affected Bone and Cartilage.Diagnostics (Basel, Switzerland) · 2024Article
- Physioxia Stimulates Extracellular Matrix Deposition and Increases Mechanical Properties of Human Chondrocyte-Derived Tissue-Engineered Cartilage.Frontiers in bioengineering and biotechnology · 2020Article
- Matrix Production in Chondrocytes Transfected with Sex Determining Region Y-Box 9 and Telomerase Reverse Transcriptase Genes: AnTissue engineering and regenerative medicine · 2019Article
- Changes in the appendicular skeleton during metamorphosis in the axolotl salamander (Ambystoma mexicanum).Journal of anatomy · 2018Article
- Cranial joint histology in the mallard duck (Anas platyrhynchos): new insights on avian cranial kinesis.Journal of anatomy · 2017Article
- Generation of articular chondrocytes from human pluripotent stem cells.Nature biotechnology · 2015Article
- Development of a cartilage composite utilizing porous tantalum, fibrin, and rabbit chondrocytes for treatment of cartilage defect.Journal of orthopaedic surgery and research · 2015Article
- Synthesis and intracellular transportation of type I procollagen during functional differentiation of odontoblasts.Histochemistry and cell biology · 2009Article
- Differential gene expression associated with postnatal equine articular cartilage maturation.BMC musculoskeletal disorders · 2008Article
- Comparison of age-dependent expression of aggrecan and ADAMTSs in mandibular condylar cartilage, tibial growth plate, and articular cartilage in rats.Histochemistry and cell biology · 2006Article
- Age-related changes in the expression of gelatinase and tissue inhibitor of metalloproteinase genes in mandibular condylar, growth plate, and articular cartilage in rats.Journal of molecular histology · 2005Article
- Expression of versican and ADAMTS during rat tooth eruption.Journal of molecular histology · 2005Article
- Distinctive expression of extracellular matrix molecules at mRNA and protein levels during formation of cellular and acellular cementum in the rat.The Histochemical journal · 2001Article
- Temporal and spatial gene expression of major bone extracellular matrix molecules during embryonic mandibular osteogenesis in rats.The Histochemical journal · 2001Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was designed to investigate whether or not chondrocytes in articular cartilage express type I collagen in vivo under physiological conditions. Expressions of the gene and the phenotype of type I collagen were examined in rat tibial articular cartilage in the knee joint during development. Knee joints of Wistar rats at 1, 5, and 11 weeks postnatal were fixed in 4% paraformaldehyde with or without 0.5% glutaraldehyde and decalcified in 10% EDTA. After the specimens were embedded in paraffin and serial sections made, adjacent sections were processed for immunohistochemistry and in situ hybridization for type I collagen. The epiphysis of the tibia was composed of cartilage in week- 1 rats. Formation of articular cartilage was in progress in week 5 as endochondral ossification proceeded and was completed in week 11. Anti-type I collagen antibody stained only the superficial area of the epiphysis in week 1, but the immunoreactivity was expanded into the deeper region of the articular cartilage with development in weeks 5 and 11. Hybridization signals for pro-alpha 1 (I) collagen were seen in some of chondrocytes in the epiphysis of the week-1 tibia. The most intense signals were identified in chondrocytes in week 5 and the signals appeared weaker in week 11. The present study demonstrated that chondrocytes synthesize type I collagen and accumulate the protein in the matrix during development of the articular cartilage.
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