ArticleThe Journal of physiology1995
Voltage-activated proton currents in membrane patches of rat alveolar epithelial cells.
Article in The Journal of physiology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Voltage-Gated Proton Channels in the Tree of Life.Biomolecules · 2023Review
- The role of Phe150 in human voltage-gated proton channel.iScience · 2022Article
- The HVCN1 voltage-gated proton channel contributes to pH regulation in canine ventricular myocytes.The Journal of physiology · 2022Article
- The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells.Scientific reports · 2020Article
- The solute carrier SLC9C1 is a NaNature communications · 2018Article
- HistidineThe Journal of general physiology · 2018Article
- Exotic properties of a voltage-gated proton channel from the snailThe Journal of general physiology · 2018Article
- Molecular and functional characterization of the voltage-gated proton channel in zebrafish neutrophils.Physiological reports · 2017Article
- The Hv1 proton channel responds to mechanical stimuli.The Journal of general physiology · 2016Article
- The intimate and controversial relationship between voltage-gated proton channels and the phagocyte NADPH oxidase.Immunological reviews · 2016Review
- The Voltage-Gated Proton Channel: A Riddle, Wrapped in a Mystery, inside an Enigma.Biochemistry · 2015Review
- Hv1 proton channel opening is preceded by a voltage-independent transition.Biophysical journal · 2014Article
- Philosophy of voltage-gated proton channels.Journal of the Royal Society, Interface · 2014Review
- Voltage-gated proton channels.Comprehensive Physiology · 2012Review
- Voltage-gated proton channel in a dinoflagellate.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1.Nature structural & molecular biology · 2010Article
- Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating.The Journal of physiology · 2010Article
- Detailed comparison of expressed and native voltage-gated proton channel currents.The Journal of physiology · 2008Article
- Mechanisms of acid and base secretion by the airway epithelium.The Journal of membrane biology · 2006Review
- Expression of gp91phox/Nox2 in COS-7 cells: cellular localization of the protein and the detection of outward proton currents.The Biochemical journal · 2005Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
1. Voltage-activated H(+)-selective currents were studied in cell-attached and excised, inside-out patches of membrane from rat alveolar epithelial cells in primary culture. The pH was varied from 5.5 to 7.5 in the pipette (pHo) and in the bath (pHi). 2. H+ currents in cell-attached patches exhibited activation kinetics and voltage dependence intermediate between their behaviour after excision into pH 6.5 and pH 7.5 solutions, consistent with reported pHi values for alveolar epithelial cells. 3. In inside-out patches, increasing pHo shifted the threshold voltage for activating H+ currents and the relationship between the time constant of activation of H+ currents (tau act) and voltage (V) negatively along the voltage axis by 40-50 mV (unit pH)-1. 4. Decreasing pHi shifted the activation threshold and the tau act-V relationship negatively along the voltage axis by 40-50 mV (unit pH)-1. In addition, at lower pHi the activation of H+ currents upon patch depolarization was markedly faster, with tau act increasing approximately 4- to 5-fold per unit pHi. 5. The limiting slope H+ conductance increased only by a factor of 1.7 per unit pH when pHi was lowered in the range 7.5-5.5 (at constant pHo 7.5). This result suggests that H+ permeation through voltage-activated H+ 'channels' occurs by a mechanism distinct from H+ permeation through water-filled ion channels, in which the conductance might be expected to increase in direct proportion to [H+].
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