ArticleGenetics1996
The rad9 gene of Coprinus cinereus encodes a proline-rich protein required for meiotic chromosome condensation and synapsis.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 69 citations in OpenAlex.
- Lessons on fruiting body morphogenesis from genomes and transcriptomes ofStudies in mycology · 2023Article
- Comparative transcriptome analysis of genes and metabolic pathways involved in sporulation in Ganoderma lingzhi.G3 (Bethesda, Md.) · 2022Article
- Divergent Gene Expression Following Duplication of Meiotic Genes in the Stick Insect Clitarchus hookeri.Genome biology and evolution · 2021Article
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- Comparative transcriptome analysis of dikaryotic mycelia and mature fruiting bodies in the edible mushroom Lentinula edodes.Scientific reports · 2018Article
- Strand-Specific RNA-Seq Analyses of Fruiting Body Development in Coprinopsis cinerea.PloS one · 2015Article
- Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I.Chromosoma · 2014Article
- An MSH4 homolog, stpp1, from Pleurotus pulmonarius is a "silver bullet" for resolving problems caused by spores in cultivated mushrooms.Applied and environmental microbiology · 2013Article
- Analysis of the Basidiomycete Coprinopsis cinerea reveals conservation of the core meiotic expression program over half a billion years of evolution.PLoS genetics · 2010Article
- Meiotic localization of Mre11 and Rad50 in wild type, spo11-1, and MRN complex mutants of Coprinus cinereus.Chromosoma · 2009Article
- Article
- Development of male gametophyte of Larix leptolepis Gord. with emphasis on diffuse stage of meiosis.Plant cell reports · 2008Article
- Identification and characterisation of structural maintenance of chromosome 1 (smc1) mutants of Coprinopsis cinerea.Molecular genetics and genomics : MGG · 2008Article
- Identification of cis-acting sites for condensin loading onto budding yeast chromosomes.Genes & development · 2008Article
- Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.Chromosoma · 2008Article
- Survey and expression analysis of five new chitin synthase genes in the biotrophic rust fungus Puccinia graminis.Current genetics · 2006Article
- Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.PLoS biology · 2006Article
- The laccase multi-gene family in Coprinopsis cinerea has seventeen different members that divide into two distinct subfamilies.Current genetics · 2006Article
- DNA topoisomerase II interacts with Lim15/Dmc1 in meiosis.Nucleic acids research · 2005Article
- Drosophila nipped-B protein supports sister chromatid cohesion and opposes the stromalin/Scc3 cohesion factor to facilitate long-range activation of the cut gene.Molecular and cellular biology · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The rad9 gene of Coprinus cinereus is essential for the normal completion of meiosis. We examined surface-spread preparations of wild-type and rad9-1 nuclei from the meiotic stages of karyogamy through metaphase I, and we determined the primary sequence, structure, and meiotic expression of the rad9 gene. In wild-type C. cinereus, karyogamy is followed by condensation and alignment of homologous chromosomes. Condensation and axial core development largely precede synapsis, which often initiates at telomeres. A diffuse diplotene phase coincides with dissolution of the synaptonemal complex, and subsequently chromosomes further condense as the cells progress into metaphase I. In contrast, although karyogamy and nucleolar fusion are apparently normal in rad9-1 basidia, only short stretches of synaptonemal complex form. These correlate with stretches of condensed chromatin, mostly at apparent chromosome ends, and regions of presumptive triple synapsis are numerous. rad9-1 basidia enter the diffuse stage of early diplotene, and then 50% of these cells enter metaphase I by the criteria of nucleolar elimination and at least some chromatin condensation. rad9 gene expression is induced after gamma irradiation and during meiosis. The gene has 27 exons and encodes a predicted protein of 2157 amino acids, with a proline-rich amino terminus.
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