ArticleGenetics1996
Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- The yeast cap binding complex modulates transcription factor recruitment and establishes proper histone H3K36 trimethylation during active transcription.Molecular and cellular biology · 2013Article
- The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNA.RNA (New York, N.Y.) · 2009Article
- Yeast cap binding complex impedes recruitment of cleavage factor IA to weak termination sites.Molecular and cellular biology · 2007Article
- Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae.Molecular and cellular biology · 2003Article
- Role of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.Molecular and cellular biology · 2001Article
- A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination.Genetics · 2001Article
- The role of nuclear cap binding protein Cbc1p of yeast in mRNA termination and degradation.Molecular and cellular biology · 2000Article
- The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA.Molecular and cellular biology · 1999Article
- Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae.RNA (New York, N.Y.) · 1999Article
- Molecular genetics of the RNA polymerase II general transcriptional machinery.Microbiology and molecular biology reviews : MMBR · 1998Review
- The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability.Genes & development · 1997Article
- Article
- Recombination between DNA repeats in yeast hpr1delta cells is linked to transcription elongation.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
To study the functions of DNA topoisomerase I and Hpr1 protein, a suppressor mutant of the temperature-sensitive growth of an hpr1 top1-5ts double mutant was isolated. The isolated triple mutant showed cold-sensitive growth. By complementation of this phenotype, the suppressor gene was cloned. DNA sequencing showed it to be GCR3, a gene involved in the expression of glycolytic genes. Further analysis showed that gcr3 mutations also suppressed the temperature-sensitive growth of hpr1 single mutants. Experiments with gcr3 truncation mutants also suggested a genetic interaction between GCR3 and HPR1. The fact that top1 suppressed the growth defect of gcr3 suggested an interaction between those two genes also. Plasmid DNA isolated from gcr3 mutants was significantly more negatively supercoiled than normal, suggesting that Gcr3 protein, like topoisomerase I and Hpr1p, affects chromatin structure, perhaps during transcription.
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