ReviewClinical rheumatology1995
B lymphocytes and humoral immune responses in rheumatoid arthritis.
Review in Clinical rheumatology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- A study on FoxP3 and Tregs in paired samples of peripheral blood and synovium in rheumatoid arthritis.Central-European journal of immunology · 2015Article
- The levels of CD16/Fc gamma receptor IIIA on CD14+ CD16+ monocytes are higher in children with severe Plasmodium falciparum anemia than in children with cerebral or uncomplicated malaria.Infection and immunity · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the etiology of rheumatoid arthritis (RA) remains unknown at present, major evidence implicates humoral immune mechanisms in the pathophysiology of this disease. The primary lesions occur in the synovium and are characterized by immunological activation and chronic inflammation. Activated B cells and plasma cells secrete antibodies including rheumatoid factors and anticollagen antibodies. These antibodies give rise to immune complex formation and activation of the inflammatory cascade. There is no evidence that rheumatoid factor secreting B cells act as antigen presenting cells and present immune complex to T cells, leading to perpetuation of the inflammatory response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.