ReviewJournal of molecular medicine (Berlin, Germany)1996
The role of Candida albicans secreted aspartic proteinase in the development of candidoses.
Review in Journal of molecular medicine (Berlin, Germany), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- Polyphyllin I EffectsEvidence-based complementary and alternative medicine : eCAM · 2023Article
- Sub-MICs of Carum copticum and Thymus vulgaris influence virulence factors and biofilm formation in Candida spp.BMC complementary and alternative medicine · 2014Article
- Candida albicans VPS4 contributes differentially to epithelial and mucosal pathogenesis.Virulence · 2014Article
- Evolutionary patterns of proteinase activity in attine ant fungus gardens.BMC microbiology · 2011Article
- Candida albicans VPS4 is required for secretion of aspartyl proteases and in vivo virulence.Mycopathologia · 2009Article
- Candida albicans and Candida tropicalis in oral candidosis: quantitative analysis, exoenzyme activity, and antifungal drug sensitivity.Mycopathologia · 2009Article
- Vesicular Trans-Cell Wall Transport in Fungi: A Mechanism for the Delivery of Virulence-Associated Macromolecules?Lipid insights · 2008Article
- Induction of secretory aspartyl proteinase of Candida albicans by HIV-1 but not HSV-2 or some other microorganisms associated with vaginal environment.Mycopathologia · 2005Article
- Candida albicans secreted aspartyl proteinases in virulence and pathogenesis.Microbiology and molecular biology reviews : MMBR · 2003Review
- Cell-associated collagenolytic activity by Candida albicans.Mycopathologia · 2002Article
- Requirement for either a host- or pectin-induced pectate lyase for infection of Pisum sativum by Nectria hematococca.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Effects of the human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients.Antimicrobial agents and chemotherapy · 1999Article
- Lack of ritonavir antifungal effect in vitro.Antimicrobial agents and chemotherapy · 1999Article
- Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence.Infection and immunity · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although Candida albicans infections in humans are increasingly frequent, our understanding of the host-parasite relationship is limited. The secreted aspartic proteinase of C. albicans was first described in 1965 and has proved to be a major factor in virulence. This enzyme belongs to the class of aspartic proteinases which includes pepsin and renin in humans. Although found in some fungi, secreted aspartic proteinase is rare in these organisms. While the existence of several isoenzymes may not be fully established, it is now obvious that at least seven different genes encode for secreted aspartic proteinase. Within Candida cells it is located in membrane-bound vesicles. Upon fusion of these subcellular structures within the plasma membrane, the enzyme is released to the environment. In the context of human mucosal diseases it is responsible both for adhesion and invasion. Strains from HIV-infected patients with oral candidosis generally exhibit higher enzymatic activity than control strains. In future secreted aspartic proteinase may prove a prime target for new types of antimycotics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.