ArticleGenetics1996
Length variation of CAG/CAA trinucleotide repeats in natural populations of Drosophila melanogaster and its relation to the recombination rate.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses.Molecular biology and evolution · 2020Article
- Amino acid repeats cause extraordinary coding sequence variation in the social amoeba Dictyostelium discoideum.PloS one · 2012Article
- Mutational dynamics of microsatellites.Molecular biotechnology · 2010Review
- Polyglutamine expansion in Drosophila: thermal stress and Hsp70 as selective agents.Journal of biosciences · 2007Review
- Article
- Contrasted polymorphism patterns in a large sample of populations from the evolutionary genetics model Drosophila simulans.Genetics · 2006Article
- Article
- Quantitative trait loci for cuticular hydrocarbons associated with sexual isolation between Drosophila simulans and D. sechellia.Genetics · 2005Article
- Allele excess at neutrally evolving microsatellites and the implications for tests of neutrality.Proceedings. Biological sciences · 2004Article
- Article
- Article
- Factors affecting polymorphism at microsatellite loci in bread wheat [ Triticum aestivum (L.) Thell]: effects of mutation processes and physical distance from the centromere.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004Article
- Microsatellite allele sizes: a simple test to assess their significance on genetic differentiation.Genetics · 2003Article
- Article
- Mutation patterns at dinucleotide microsatellite loci in humans.American journal of human genetics · 2002Article
- Chromosomal patterns of microsatellite variability contrast sharply in African and non-African populations of Drosophila melanogaster.Genetics · 2002Article
- Genetic diversity in Leavenworthia populations with different inbreeding levels.Proceedings. Biological sciences · 1998Article
- Microsatellite polymorphism in natural populations of the wild plant Arabidopsis thaliana.Genetics · 1997Article
- Natural selection and the frequency distributions of "silent" DNA polymorphism in Drosophila.Genetics · 1997Article
- Polymorphism and locus-specific effects on polymorphism at microsatellite loci in natural Drosophila melanogaster populations.Genetics · 1997Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Eleven genes distributed along the Drosophila melanogaster chromosome 2 and showing exonic tandem repeats of glutamine codons (CAG or CAA) were surveyed for length variation in a sample of four European and African populations. Only one gene was monomorphic. Eight genes were polymorphic in all populations, with a total number of alleles varying between five and 12 for 120 chromosomes. The average heterozygozity per locus and population was 0.41. Selective neutrality in length variation could not be rejected under the assumptions of the infinite allele model. Significant population subdivision was found though no geographical pattern emerged, all populations being equally different. Significant linkage disequilibrium was found in four out of seven cases where the genetic distance between loci was < 1 cM and was negligible when the distance was larger. There is evidence that these associations were established after the populations separated. An unexpected result was that variation at each locus was independent of the coefficient of exchange, although the latter ranged from zero to the relatively high value of 6.7%. This would indicate that background selection and selective hitchhiking, which are thought to affect levels of nucleotide substitution polymorphism, have no effect on trinucleotide repeat variation.
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