ArticleGenetics1996
The product of the het-C heterokaryon incompatibility gene of Neurospora crassa has characteristics of a glycine-rich cell wall protein.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 77 citations in OpenAlex.
- Genetic mapping and nuclear interactions of an incompatibility response in Agaricus bisporus.G3 (Bethesda, Md.) · 2026Article
- het-B allorecognition in Podospora anserina is determined by pseudo-allelic interaction of genes encoding a HET and lectin fold domain protein and a PII-like protein.PLoS genetics · 2024Article
- Lineage-specific genes are clustered with HET-domain genes and respond to environmental and genetic manipulations regulating reproduction in Neurospora.PLoS genetics · 2023Article
- Proteome Analyses RevealACS omega · 2020Article
- Molecular Mechanisms Regulating Cell Fusion and Heterokaryon Formation in Filamentous Fungi.Microbiology spectrum · 2017Review
- The genome and development-dependent transcriptomes of Pyronema confluens: a window into fungal evolution.PLoS genetics · 2013Article
- Article
- Transcriptional profiling and functional analysis of heterokaryon incompatibility in Neurospora crassa reveals that reactive oxygen species, but not metacaspases, are associated with programmed cell death.Microbiology (Reading, England) · 2009Article
- Identification of the het-r vegetative incompatibility gene of Podospora anserina as a member of the fast evolving HNWD gene family.Current genetics · 2009Article
- VIB-1 is required for expression of genes necessary for programmed cell death in Neurospora crassa.Eukaryotic cell · 2006Article
- The homologue of het-c of Neurospora crassa lacks vegetative compatibility function in Fusarium proliferatum.Applied and environmental microbiology · 2006Article
- A nonself recognition gene complex in Neurospora crassa.Genetics · 2006Article
- Article
- Comparative analysis of programmed cell death pathways in filamentous fungi.BMC genomics · 2005Article
- Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.Eukaryotic cell · 2004Article
- Chromosome rearrangements in isolates that escape from het-c heterokaryon incompatibility in Neurospora crassa.Current genetics · 2004Article
- Fatal attraction: nonself recognition and heterokaryon incompatibility in filamentous fungi.Eukaryotic cell · 2003Review
- Nonself recognition is mediated by HET-C heterocomplex formation during vegetative incompatibility.The EMBO journal · 2002Article
- Identification of vib-1, a locus involved in vegetative incompatibility mediated by het-c in Neurospora crassa.Genetics · 2002Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filamentous fungi are capable of hyphal fusion, but heterokaryon formation between different isolates is controlled by specific loci termed het loci. Heterokaryotic cells formed between strains of different het genotype are rapidly destroyed or strongly inhibited in their growth. In Neurospora crassa, at least 11 loci, including the mating type locus, affect the capacity to form a heterokaryon between different isolates. In this report, we describe the molecular characterization of the vegetative incompatibility locus, het-C. The het-COR allele was cloned by genetically identifying the het-C locus in a chromosome walk, and the activity of clones containing the het-COR allele was tested in a functional transformation assay. The het-COR allele encodes a 966-amino acid polypeptide with a putative signal peptide, a coiled-coil motif and a C-terminal glycine-rich domain, similar to glycine-rich domains detected in various extracellular and structural cell envelope proteins. Both the coiled-coil and one-third of the glycine-rich carboxyl terminal domains were required for full het-COR activity. Mutants of het-COR were obtained by repeat-induced point mutation (RIP); these mutants were indistinguishable from wild type during vegetative growth and sexual reproduction but displayed dual compatibility with both of two mutually incompatible het-COR and het-cPA strains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.