ArticleGenetics1996
Mutations in the yeast SRB2 general transcription factor suppress hpr1-induced recombination and show defects in DNA repair.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- MED20 mutation associated with infantile basal ganglia degeneration and brain atrophy.European journal of pediatrics · 2015Article
- Transcription and recombination: when RNA meets DNA.Cold Spring Harbor perspectives in biology · 2014Review
- Sumoylation of the THO complex regulates the biogenesis of a subset of mRNPs.Nucleic acids research · 2014Article
- Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability.Nucleic acids research · 2011Article
- New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.Molecular and cellular biology · 2011Article
- A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants.Molecular genetics and genomics : MGG · 2008Article
- Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes.Molecular biology of the cell · 2007Article
- Genetic interactions of DST1 in Saccharomyces cerevisiae suggest a role of TFIIS in the initiation-elongation transition.Genetics · 2004Article
- A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Role of transcription in plasmid maintenance in the hpr1Delta mutant of Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae.Molecular and cellular biology · 2002Article
- High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses hpr1-mediated genomic instability.Molecular and cellular biology · 2001Article
- BRCA1 at a branch point.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae.The EMBO journal · 2000Article
- The Saccharomyces cerevisiae hyperrecombination mutant hpr1Delta is synthetically lethal with two conditional alleles of the acetyl coenzyme A carboxylase gene and causes a defect in nuclear export of polyadenylated RNA.Molecular and cellular biology · 1999Article
- A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.The EMBO journal · 1998Article
- Molecular genetics of the RNA polymerase II general transcriptional machinery.Microbiology and molecular biology reviews : MMBR · 1998Review
- The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain.Genes & development · 1998Article
- The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability.Genes & development · 1997Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have obtained genetic and molecular evidence that the hrs2-1 mutation, isolated as a suppressor of the hyperrecombination phenotype of hpr1 delta, is in the SRB2 gene, which encodes a component of the RNA polII holoenzyme. A newly constructed srb2 delta allele restores the wild-type levels of deletions in hpr1 delta cells, indicating that the lack of a functional SRB2 transcription factor suppresses recombination between direct repeats. These results suggest a direct connection between transcription and recombination between DNA repeats. On the other hand, the hrs2-1 mutation (renamed srb2-101), in which Gly150 has been changed to Asp, makes cells sensitive to long MMS treatments, a phenotype observed for the srb2 delta null allele only in a hpr1 delta background. This indicates that mutations in the basal transcription factor SRB2 impair DNA repair of MMS-induced damage, which adds a new connection between transcription and DNA repair. We discuss the possibility that hpr1-induced deletions occurred as a consequence of a SRB2-dependent stalled or blocked transcription complex.
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