Evidence map›Paper›PMID 8844123›Full record

ArticleArchives of dermatological research1996

IgA antikeratinocyte surface autoantibodies from two types of intercellular IgA vesiculopustular dermatosis recognize distinct isoforms of desmocollin.

T Hashimoto, T Ebihara, M Dmochowski, K Kawamura, T Suzuki, S Tsurufuji, D R Garrod, T Nishikawa

Abstract read
PubMed
In one paragraph

Article in Archives of dermatological research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

T HashimotoDepartment of Dermatology, Keio University School of Medicine, Tokyo, Japan.
T Ebihara
M Dmochowski
K Kawamura
T Suzuki
S Tsurufuji
D R Garrod
T Nishikawa
University of Manchester · GBUniversity School of Physical Education in Kraków · PLKeio University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously proposed the term intercellular IgA vesiculopustular dermatosis (IAVPD) for cases showing IgA antikeratinocyte surface autoantibodies. This condition is divided into two subtypes: intraepidermal neutrophilic IgA dermatosis (IEN), showing pustule formation in the entire epidermis, and subcorneal pustular dermatosis (SPD) showing pustule formation in the uppermost epidermis. We have previously reported that serum from certain IAVPD patients reacts with bovine desmocollin (Dsc), a desmosomal cadherin. In this study we showed that two Dsc isoforms with a slightly different molecular weight were recognized by the serum from these patients. Further analysis revealed that serum from patients with the SPD type, which stained the cell surface in the uppermost epidermis with immunofluorescence, seem to react with Dsc1. By contrast, serum from patients with the IEN type, which stained the cell surface at all levels of the epidermis with immunofluorescence, seemed to react with Dsc3. This difference of distribution between the two distinct Dsc molecules may contribute to the different clinicopathological features between the IEN and SPD type of IAVPD.

Indexed as

AutoantibodiesCell Adhesion MoleculesCell MembraneCytoskeletal ProteinsDesmocollinsDesmoplakinsDesmosomesFluorescent Antibody TechniqueHumansImmunoblottingImmunoglobulin AKeratinocytesRecombinant Fusion ProteinsSkin Diseases, VesiculobullousTissue ExtractsAutoantibodiesCell Adhesion MoleculesCytoskeletal ProteinsDesmocollinsDesmoplakinsImmunoglobulin ARecombinant Fusion ProteinsTissue Extracts

Identifiers

PMID8844123
OpenAlexW1993950690

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.