Evidence map›Paper›PMID 8844119›Full record

ArticleArchives of dermatological research1996

Differential expression of CRABP II, psoriasin and cytokeratin 1 mRNA in human skin diseases.

B Algermissen, J Sitzmann, P LeMotte, B Czarnetzki

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Archives of dermatological research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Pathogenic role of S100 proteins in psoriasis.Frontiers in immunology · 2023
    Review
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  17. Psoriasin (S100A7) is significantly up-regulated in human epithelial skin tumours.Journal of cancer research and clinical oncology · 2007
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

B AlgermissenDepartment of Dermatology, Virchow Klinikum, Humboldt-University zu Berlin, Germany.
J Sitzmann
P LeMotte
B Czarnetzki
Humboldt-Universität zu Berlin · DERoche (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to confirm and further explore the significance of the overexpression of the CRABP II (cellular retinoic acid binding protein type II) and psoriasin genes in psoriatic versus normal skin, we examined the mRNA expression levels of these two genes by in situ hybridization in skin samples from psoriatic plaques and in one case from the border between a psoriatic plaque and uninvolved skin. Both genes were markedly upregulated in lesional skin, with a shift from low to high expression in the transitional zone of the plaque. Expression of the cytokeratin 1 (K1) gene was, in contrast, high in normal skin and decreased in the transition from uninvolved skin to psoriatic plaque, Examination of mRNA levels of CRABP II and psoriasin in other hyperproliferative and inflammatory skin diseases showed high expression of psoriasin, and in some cases also of CRABP II, in atopic dermatitis, mycosis fungoides, Darier's disease and inflammatory lichen sclerosus et atrophicus. In atrophic lesions of lichen sclerosus et atrophicus that lacked an inflammatory infiltrate, these changes were only weakly expressed. These findings demonstrate that altered epidermal gene expression of K1, psoriasin and CRABP II is not disease-specific and may reflect instead an altered state of epidermal differentiation and/or may be linked to the inflammation and cellular infiltration common to all the conditions studied.

Indexed as

BiopsyCalcium-Binding ProteinsCase-Control StudiesHumansKeratinsPsoriasisReceptors, Retinoic AcidRNA, MessengerS100 Calcium Binding Protein A7S100 ProteinsCalcium-Binding ProteinsKeratinsReceptors, Retinoic Acidretinoic acid binding protein II, cellularRNA, MessengerS100A7 protein, humanS100 Calcium Binding Protein A7S100 Proteins

Identifiers

PMID8844119
OpenAlexW2046960963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.