ArticleBritish journal of pharmacology1996
Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Mechanism of action of two potent LRRC8/VRAC channel inhibitors.Research square · 2026Article
- Inhibition of Pore-Forming Proteins.Toxins · 2019Review
- An Exploration of Charge Compensating Ion Channels across the Phagocytic Vacuole of Neutrophils.Frontiers in pharmacology · 2017Article
- The LRRC8A Mediated "Swell Activated" Chloride Conductance Is Dispensable for Vacuolar Homeostasis in Neutrophils.Frontiers in pharmacology · 2017Article
- Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas.The Journal of membrane biology · 2003Article
- Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1.British journal of pharmacology · 2001Article
- Quinine blocks specific gap junction channel subtypes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Block by fluoxetine of volume-regulated anion channels.British journal of pharmacology · 1999Article
- Activation of volume-regulated chloride currents by reduction of intracellular ionic strength in bovine endothelial cells.The Journal of physiology · 1998Article
- Regulation of a swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins.The Journal of physiology · 1998Article
- Membrane currents and the resting membrane potential in cultured bovine pulmonary artery endothelial cells.The Journal of physiology · 1996Article
- Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.Channels (Austin, Tex.)Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of quinine and quinidine on the volume-activated chloride current (ICl(vol)) in cultured endothelial cells from bovine pulmonary artery were studied by use of the whole-cell patch-clamp technique. 2. At pH 7.4 both quinine and quinidine induced a fast and reversible block of ICl(vol)) with Ki values of 20 +/- 4 microM and 30 +/- 10 microM, respectively. 3. The blocking efficiency of both drugs increased dramatically with increasing extracellular pH, indicating that the blockade is mediated by the uncharged form of quinine and quinidine. 4. These results suggest a hydrophobic interaction with high affinity between volume-activated chloride channels and uncharged quinine and quinidine within the membrane bilayer of endothelial cells.
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