Evidence map›Paper›PMID 8842147›Full record

ArticleMolecular & general genetics : MGG1996

Transcription of mutS and mutL-homologous genes in Saccharomyces cerevisiae during the cell cycle.

W Kramer, B Fartmann, E C Ringbeck

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular & general genetics : MGG, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

W KramerInstitut für Molekulare Genetik, Georg-August-Universität, Göttingen, Germany.
B Fartmann
E C Ringbeck
University of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcription of the Saccharomyces cerevisiae DNA mismatch repair genes PMS1, MSH2, and MSH6, a recently discovered homolog of the Escherichia coli mutS gene, was shown to be cell cycle regulated. In contrast, transcription of the MSH1, MSH3 and MLH1 genes was not regulated during the cell cycle. The MSH1 gene, which is thought to be involved in DNA mismatch repair in mitochondria, was also not induced under aerobic growth conditions. Regulation of the PMS1 gene was dependent on intact MluI cell cycle boxes, as demonstrated by analysis of a promoter mutant. Both reduced and increased expression of PMS1 resulted in a mitotic mutator phenotype. Analysis of mRNA levels was performed with a newly developed reverse transcription-PCR (polymerase chain reaction) approach using fluorescently labeled primers and an automated DNA sequencer for detection of PCR products.

Indexed as

Adenosine TriphosphatasesCarrier ProteinsEscherichia coli ProteinsSaccharomyces cerevisiae ProteinsTranscription, GeneticAdaptor Proteins, Signal TransducingBacterial ProteinsCell CycleDNA-Binding ProteinsDNA RepairEscherichia coliFungal ProteinsGene ExpressionGene Expression Regulation, FungalMitochondrial ProteinsMutationAdaptor Proteins, Signal TransducingAdenosine TriphosphatasesBacterial ProteinsCarrier ProteinsDNA-Binding ProteinsEscherichia coli ProteinsFungal ProteinsMitochondrial ProteinsMLH1 protein, S cerevisiaeMSH1 protein, S cerevisiaeMSH2 protein, S cerevisiaeMSH3 protein, S cerevisiaeMSH6 protein, S cerevisiaeMutL protein, E coliMutL Protein Homolog 1MutL ProteinsMutS DNA Mismatch-Binding ProteinMutS Homolog 2 ProteinMutS Homolog 3 ProteinMutS protein, E coliPMS1 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID8842147
OpenAlexW2320929094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.