ReviewPharmaceutical research1996
Carrier-mediated intestinal transport of drugs.
Review in Pharmaceutical research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 390 citations in OpenAlex.
- Potential herb‒drug interactions between anti-COVID-19 drugs and traditional Chinese medicine.Acta pharmaceutica Sinica. B · 2023Review
- Challenges and Opportunities in the Oral Delivery of Recombinant Biologics.Pharmaceutics · 2023Review
- Advances in Oral Drug Delivery.Frontiers in pharmacology · 2021Review
- Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties.Frontiers in nutrition · 2021Review
- A Review of the Ethnopharmacology, Phytochemistry, Pharmacology, Application, Quality Control, Processing, Toxicology, and Pharmacokinetics of the Dried Rhizome ofFrontiers in pharmacology · 2021Review
- Article
- The Segregated Intestinal Flow Model (SFM) for Drug Absorption and Drug Metabolism: Implications on Intestinal and Liver Metabolism and Drug-Drug Interactions.Pharmaceutics · 2020Review
- Non-invasive delivery strategies for biologics.Nature reviews. Drug discovery · 2019Review
- Glutathione sulfotransferase inhibition activity of a self-fermented beverage, Kanji.Pharmaceutical biology · 2017Article
- Therapeutic applications of hydrogels in oral drug delivery.Expert opinion on drug delivery · 2014Review
- The pharmacology of novel oral anticoagulants.Journal of thrombosis and thrombolysis · 2014Review
- Approaches for enhancing oral bioavailability of peptides and proteins.International journal of pharmaceutics · 2013Review
- Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins.Clinical and experimental nephrology · 2011Review
- Uptake/efflux transport of tramadol enantiomers and O-desmethyl-tramadol: focus on P-glycoprotein.Basic & clinical pharmacology & toxicology · 2009Article
- Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp).Pharmaceutical research · 2009Article
- Quantitative evaluation of PEPT1 contribution to oral absorption of cephalexin in rats.Pharmaceutical research · 2009Article
- Pharmacokinetics of amino acid ester prodrugs of acyclovir after oral administration: interaction with the transporters on Caco-2 cells.International journal of pharmaceutics · 2008Article
- Past, present, and future technologies for oral delivery of therapeutic proteins.Journal of pharmaceutical sciences · 2008Review
- Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats.Pharmaceutical research · 2008Article
- The design of guanidinium-rich transporters and their internalization mechanisms.Advanced drug delivery reviews · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent advances in the field of carrier-mediated intestinal absorption of of amino acids, oligopeptides, monosaccharides, monocarboxylic acids, phosphate, bile acids and several water-soluble vitamins across brush-border and basolateral membranes are summarized. An understanding of the molecular and functional characteristics of the intestinal membrane transporters will be helpful in the utilization of these transporters for the enhanced oral delivery of poorly absorbed drugs. Some successful examples of the synthesis of prodrugs recognized by the targeted transporters are described. Functional expression of the multidrug resistance gene product, P-glycoprotein, as a primary active transporter in the intestinal brush-border membrane leads to net secretion of some drugs such as anticancer agents in the blood-to-luminal direction, serving as a secretory detoxifying mechanism and as a part of the absorption barrier in the intestine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.