ArticleAnnals of biomedical engineering
Video microscopy to quantitate the inhomogeneous equilibrium strain within articular cartilage during confined compression.
Article in Annals of biomedical engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 165 citations in OpenAlex.
- Shear Mechanics of Articular Cartilage and Cartilage-Inspired Materials.Annual review of condensed matter physics · 2026Article
- In Situ Loading and Time-Resolved Synchrotron-Based Phase Contrast Tomography for the Mechanical Investigation of Connective Knee Tissues: A Proof-of-Concept Study.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Depth-Dependent Strain Model (1D) for Anisotropic Fibrils in Articular Cartilage.Materials (Basel, Switzerland) · 2024Article
- Apparatus and Method for Rapid Detection of Acoustic Anisotropy in Cartilage.Journal of medical and biological engineering · 2020Article
- Recombinant human FGF18 preserves depth-dependent mechanical inhomogeneity in articular cartilage.European cells & materials · 2019Article
- Regulation of lubricin for functional cartilage tissue regeneration: a review.Biomaterials research · 2018Review
- Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage.Acta biomaterialia · 2017Article
- Scaffold-free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling.Journal of tissue engineering and regenerative medicine · 2017Article
- Finite element modeling of finite deformable, biphasic biological tissues with transversely isotropic statistically distributed fibers: toward a practical solution.Zeitschrift fuer angewandte mathematik und physik · 2016Article
- Mapping Chondrocyte Viability, Matrix Glycosaminoglycan, and Water Content on the Surface of a Bovine Metatarsophalangeal Joint.Cartilage · 2016Article
- Cartilage Strain Distributions Are Different Under the Same Load in the Central and Peripheral Tibial Plateau Regions.Journal of biomechanical engineering · 2015Article
- Does periacetabular osteotomy have depth-related effects on the articular cartilage of the hip?Clinical orthopaedics and related research · 2015Article
- Measuring microscale strain fields in articular cartilage during rapid impact reveals thresholds for chondrocyte death and a protective role for the superficial layer.Journal of biomechanics · 2015Article
- Biomechanical evaluation of human and porcine auricular cartilage.The Laryngoscope · 2015Article
- Depth-dependent shear behavior of bovine articular cartilage: relationship to structure.Journal of anatomy · 2014Article
- The mechanobiology of articular cartilage: bearing the burden of osteoarthritis.Current rheumatology reports · 2014Review
- Strain-dependent oxidant release in articular cartilage originates from mitochondria.Biomechanics and modeling in mechanobiology · 2014Article
- Localization of viscous behavior and shear energy dissipation in articular cartilage under dynamic shear loading.Journal of biomechanical engineering · 2013Article
- Multimodal evaluation of tissue-engineered cartilage.Journal of medical and biological engineering · 2013Article
- Of mice, men and elephants: the relation between articular cartilage thickness and body mass.PloS one · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The objectives of this study were to develop a method to quantitate the displacement and strain fields within articular cartilage during equilibrium confined compression, and to use the method to determine the variation of the equilibrium confined compression modulus with depth from the articular surface in bovine cartilage. The method made use of fluorescently labeled chondrocyte nuclei as intrinsic fiducial markers. Articular cartilage was harvested from the patellofemoral groove of adult bovines and trimmed to rectangular blocks 5 mm long, 0.76 mm wide, and 500 microns deep with the articular surface intact. Test specimens were stained with the DNA binding dye Hoechst 33258, placed in a custom confined compression chamber, and viewed with an epifluorescence microscope equipped for video image acquisition. Image processing was used to localize fluorescing chondrocyte nuclei in uncompressed and compressed (approximately 17%) specimens, allowing determination of the intra-tissue displacement profile. Strain was determined as the slope of linear regression fits of the displacement data in four sequential 125-microns-thick layers. Equilibrium strains varied 6.1-fold from the articular surface through 500 microns of cartilage depth, with the greatest compressive strain in the superficial 125-microns layer and the least compressive strain in the two deepest 125-microns layers. Thus, the four successive 125-microns layers have moduli that are 0.44 (superficial), 1.07, 2.39, and 2.67 (deep) times the apparent modulus for a 500-microns thick cartilage sample assumed to be homogeneous.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.