ReviewAnnals of biomedical engineering
1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
Review in Annals of biomedical engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 81 citations in OpenAlex.
- A Phase II study of pulse dose imatinib mesylate and weekly paclitaxel in patients aged 70 and over with advanced non-small cell lung cancer.BMC cancer · 2012Trial
- Tracer kinetic modeling of a 14 kDa anti-CD8 PET tracer (2C8v144) for in vivo estimation of CD8 expression in tissue and blood, binding affinity, and total body receptor occupancy.Journal of pharmacokinetics and pharmacodynamics · 2026Article
- Mathematical model of oxygen, nutrient, and drug transport in tuberculosis granulomas.PLoS computational biology · 2024Article
- Article
- Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.Trends in cancer · 2018Review
- Targeting VEGF pathway to normalize the vasculature: an emerging insight in cancer therapy.OncoTargets and therapy · 2018Review
- Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Review
- A novel peptide (Thx) homing to non-small cell lung cancer identified by ex vivo phage display.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013Article
- Mechanical control of spheroid growth: distinct morphogenetic regimes.Journal of biomechanics · 2012Article
- Monitoring the longitudinal intra-tumor physiological impulse response to VEGFR2 blockade in breast tumors using DCE-CT.Molecular imaging and biology · 2011Article
- A novel peptide enhances therapeutic efficacy of liposomal anti-cancer drugs in mice models of human lung cancer.PloS one · 2009Article
- Vascular permeability, vascular hyperpermeability and angiogenesis.Angiogenesis · 2008Review
- Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts.British journal of cancer · 2007Article
- Noninvasive methods to study drug distribution.Investigational new drugs · 2003Review
- Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation.The American journal of pathology · 2001Article
- Quantitation of HSV mass distribution in a rodent brain tumor model.Gene therapy · 2000Article
- Causes and effects of heterogeneous perfusion in tumors.Neoplasia (New York, N.Y.) · 1999Review
- Tumor vascular endothelium: barrier or target in tumor directed drug delivery and immunotherapy.Pharmaceutical research · 1997Review
- Leukocyte-endothelial adhesion and angiogenesis in tumors.Cancer metastasis reviews · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To reach cancer cells in a tumor, a blood-borne therapeutic agent must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then to integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.