Evidence map›Paper›PMID 8840786›Full record

ReviewMicrobiological reviews1996

Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

J R Govan, V Deretic

Open access · diamondAbstract readReview
In one paragraph

Review in Microbiological reviews, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 729 papers.

0numbers the graph read from it
0cells of the map it votes in
729citing papers in PubMed
41.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

729 citing papers in PubMed, 1,659 citations in OpenAlex.

  1. Article
  2. Review
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  20. Article

669 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J R GovanDepartment of Medical Microbiology, University of Edinburgh Medical School, Scotland.
V Deretic
University of Edinburgh · GB

Funding

PSEUDOMONAS IN CYSTIC FIBROSIS--REGULATION OF MUCOIDYR01AI031139 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DERETIC, VOJO P · 1992 to 2006
$2.5M
NIAID NIH HHS AI31139
6 · The paper itself

Abstract

Respiratory infections with Pseudomonas aeruginosa and Burkholderia cepacia play a major role in the pathogenesis of cystic fibrosis (CF). This review summarizes the latest advances in understanding host-pathogen interactions in CF with an emphasis on the role and control of conversion to mucoidy in P. aeruginosa, a phenomenon epitomizing the adaptation of this opportunistic pathogen to the chronic chourse of infection in CF, and on the innate resistance to antibiotics of B. cepacia, person-to-person spread, and sometimes rapidly fatal disease caused by this organism. While understanding the mechanism of conversion to mucoidy in P. aeruginosa has progressed to the point where this phenomenon has evolved into a model system for studying bacterial stress response in microbial pathogenesis, the more recent challenge with B. cepacia, which has emerged as a potent bona fide CF pathogen, is discussed in the context of clinical issues, taxonomy, transmission, and potential modes of pathogenicity.

Indexed as

AlginatesAmino Acid SequenceBase SequenceBurkholderia InfectionsCystic FibrosisDisease SusceptibilityHumansMolecular Sequence DataPseudomonas InfectionsVirulenceAlginates

Identifiers

PMID8840786
PMCPMC239456
OpenAlexW2169545551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.