ArticleTransgenic research1996
Human placental alkaline phosphatase as a histochemical marker of gene expression in transgenic mice.
Article in Transgenic research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed, 59 citations in OpenAlex.
- Development of a heat-stable alkaline phosphatase reporter system for cis-regulatory analysis and its application to 3D digital imaging of Xenopus embryonic tissues.Development, growth & differentiation · 2024Article
- Tissue-Nonspecific Alkaline Phosphatase, a Possible Mediator of Cell Maturation: Towards a New Paradigm.Cells · 2021Review
- Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche.Neuron · 2014Article
- MRI-based detection of alkaline phosphatase gene reporter activity using a porphyrin solubility switch.Chemistry & biology · 2014Article
- Characterization of a heat resistant beta-glucosidase as a new reporter in cells and mice.BMC biology · 2010Article
- Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Modeling variation in tumors in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Six1 and Eya1 expression can reprogram adult muscle from the slow-twitch phenotype into the fast-twitch phenotype.Molecular and cellular biology · 2004Article
- Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.Molecular and cellular biology · 2003Article
- Diversity at the locus associated with transcription of a variable surface antigen of Pneumocystis carinii as an index of population structure and dynamics in infected rats.Infection and immunity · 2003Article
- The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development.The EMBO journal · 2001Article
- A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cryopreserved Stem Cells Incur Damages Due To Terrestrial Cosmic Rays Impairing Their Integrity Upon Long-Term Storage.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The human placental alkaline phosphatase (PLAP) gene was analysed for its utility as a histochemically detectable reporter gene in transgenic mice. A reporter gene was made by linking the PLAP structural gene to an enhancer-promoter element from the human beta-actin gene. This gene was inserted into the mouse genome by transfection of embryonic stem cells, and by microinjection of fertilized eggs. Histochemical staining showed that the transgene was uniformly expressed in four of four stable ES cell lines, and in all ten tissues examined from adult animals from five lines of transgenic mice. Non-transgenic cells did not stain. These results suggest that the human PLAP gene will be of utility in studies requiring phenotypic marking of cells in tissues of mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.