ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology1996
Mixed oropharyngeal candidiasis due to Candida albicans and non-albicans Candida strains in HIV-infected patients.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- A randomized, double-blind, placebo-controlled clinical trial of fluoride varnish in preventing dental caries of Sjögren's syndrome patients.BMC oral health · 2016Trial
- Frequency ofAdvanced biomedical research · 2020Article
- Oral candidiasis among African human immunodeficiency virus-infected individuals: 10 years of systematic review and meta-analysis from sub-Saharan Africa.Journal of oral microbiology · 2017Review
- Candidiasis: predisposing factors, prevention, diagnosis and alternative treatment.Mycopathologia · 2014Review
- Growth inhibitory response and ultrastructural modification of oral-associated candidal reference strains (ATCC) by Piper betle L. extract.International journal of oral science · 2014Article
- Pseudomembranous candidiasis in HIV/AIDS patients in Cali, Colombia.Mycopathologia · 2013Article
- Action of Coriandrum sativum L. Essential Oil upon Oral Candida albicans Biofilm Formation.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Optimal management of oropharyngeal and esophageal candidiasis in patients living with HIV infection.HIV/AIDS (Auckland, N.Z.) · 2010Article
- Species distribution and antifungal susceptibility profile of oral candida isolates from HIV-infected patients in the antiretroviral therapy era.Mycopathologia · 2006Article
- In vitro activities of terbinafine in combination with fluconazole, itraconazole, voriconazole, and posaconazole against clinical isolates of Candida glabrata with decreased susceptibility to azoles.Journal of clinical microbiology · 2002Article
- Optimizing voriconazole susceptibility testing of Candida: effects of incubation time, endpoint rule, species of Candida, and level of fluconazole susceptibility.Journal of clinical microbiology · 1999Article
- Epidemiology of visceral mycoses: analysis of data in annual of the pathological autopsy cases in Japan.Journal of clinical microbiology · 1999Article
- Mixed Candida glabrata and Candida albicans disseminated candidiasis in a heroin addict.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Article
- Azole resistance in Candida.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1997Review
- Development of Candida-associated denture stomatitis: new insights.Journal of applied oral science : revista FOBReview
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to determine the clinical significance of mixed oropharyngeal candidiasis (Candida albicans plus a non-albicans strain of Candida) in patients infected with HIV-1, a retrospective chart review was done in 12 HIV-1-infected patients with a clinical episode of oropharyngeal candidiasis, in whom a mixed culture of Candida albicans (found to be fluconazole-sensitive) plus a non-albicans species of Candida was obtained from their oral cavities. This group was compared with 26 HIV-positive patients (control group) with oropharyngeal candidiasis due to Candida albicans (found to be fluconazole-sensitive). Antifungal susceptibility testing was performed by a broth microdilution test with RPMI-2% glucose. A fungal strain was considered fluconazole-sensitive if its MIC was < 0.5 micrograms/ml. Both the study and control groups had similar clinical and demographic characteristics. All the patients were severely immunocompromised, with a mean CD4+ lymphocyte count of 63/mm3 (95% CI 41-84) and 80/mm3 (95% CI 25-135) in the study and control groups, respectively. In the study group, seven patients had Candida albicans and Candida krusei in their oral cavity, four had Candida albicans and Candida glabrata, and one had Candida albicans and Candida tropicalis. Antifungal therapy consisted of ketoconazole (5 patients in the study group, 14 in the control group) or fluconazole (7 patients in the study group, 12 in the control group); no statistically significant difference in clinical outcome was observed. Fungal strain persistence after therapy was frequently observed in both groups. It is concluded that non-albicans strains of Candida, less sensitive to azole drugs than their Candida albicans counterparts, are not clinically relevant in episodes of mixed oropharyngeal candidiasis in HIV-1-infected patients.
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