ArticleExperimental brain research1996
Inhibitory action of dopamine involves a subthreshold Cs(+)-sensitive conductance in neostriatal neurons.
Article in Experimental brain research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- Distinct electrophysiology and dopaminergic modulation of medium spiny neurons across divisions of the tail striatum and the dorsolateral striatum.Experimental physiology · 2026Article
- Dopaminergic Inhibition of the Inwardly Rectifying Potassium Current in Direct Pathway Medium Spiny Neurons in Normal and Parkinsonian Striatum.Brain sciences · 2025Article
- Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice.bioRxiv : the preprint server for biology · 2025Article
- Updating the striatal-pallidal wiring diagram.Nature neuroscience · 2024Review
- Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals.iScience · 2023Article
- Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors.Nature communications · 2021Article
- Altered excitatory transmission in striatal neurons after chronic ethanol consumption in selectively bred crossed high alcohol-preferring mice.Neuropharmacology · 2021Article
- Article
- Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2.Frontiers in neural circuits · 2018Review
- Dopamine and Acetylcholine, a Circuit Point of View in Parkinson's Disease.Frontiers in neural circuits · 2017Review
- The serotonin 5-HTJournal of psychopharmacology (Oxford, England) · 2017Review
- BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons.Brain research · 2014Article
- New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons.The European journal of neuroscience · 2012Article
- Review
- Dopaminergic modulation of spiny neurons in the turtle striatum.Cellular and molecular neurobiology · 2010Article
- A neurocomputational model of tonic and phasic dopamine in action selection: a comparison with cognitive deficits in Parkinson's disease.Behavioural brain research · 2009Article
- Modulation of horizontal cell function by dopaminergic ligands in mammalian retina.Vision research · 2008Article
- Differential tonic GABA conductances in striatal medium spiny neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Dopaminergic modulation of axon collaterals interconnecting spiny neurons of the rat striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Brain oscillations, medium spiny neurons, and dopamine.Cellular and molecular neurobiology · 2002Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular recordings in in vitro slice preparations of rat brain were used to compare the actions of dopamine and dopamine receptor agonists on the subthreshold membrane properties of neostriatal neurons. A reproducible response for dopaminergic agonists was evoked after firing produced by current ramp injections that induced a subthreshold voltage displacement. Dopamine (10-100 microM) decreased both firing rate and membrane slope input resistance in virtually all cells tested. Input resistance change appeared as an increase in inward rectification. Approximate reversal potential was around -87 mV. The D1 receptor agonists SKF 38393 and Cl-APB (1-10 microM) mimicked both dopamine effects with a reversal potential around -89 mV. The effects were blocked by the presence of 5-10 mM caesium (Cs+) but not by 1 microM tetrodotoxin, suggesting that main D1 effects on input resistance are due to subthreshold Cs(+)-sensitive conductances. cAMP analogues mimicked the actions of D1 receptor agonists. The D2 agonist, quinpirole (1-10 microM), did not produce any input resistance change, nonetheless, it still produced a decrease in firing rate. This suggests that the main D2 effect on firing is due to actions on suprathreshold ion conductances. All effects were blocked by D1 and D2 antagonists, respectively. D1 or D2 effects were found in the majority of cells tested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.