ArticleNucleic acids research1996
Gene encoding human Ro-associated autoantigen Y5 RNA.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- YRNAs: biosynthesis, structure, functions and involvment in cancer development.Discover oncology · 2025Review
- Human sperm heads harbor modified YsRNA as transgenerationally inherited non-coding RNAs.Frontiers in genetics · 2023Article
- Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers.Cancers · 2020Review
- A guide to naming human non-coding RNA genes.The EMBO journal · 2020Review
- Y RNAs: Biogenesis, Function and Implications for the Cardiovascular System.Advances in experimental medicine and biology · 2020Review
- YRNAs overexpression and potential implications in allergy.The World Allergy Organization journal · 2019Article
- Extracellular vesicle-mediated transfer of processed and functional RNY5 RNA.RNA (New York, N.Y.) · 2015Article
- Functional roles of non-coding Y RNAs.The international journal of biochemistry & cell biology · 2015Review
- Non-coding Y RNAs as tethers and gates: Insights from bacteria.RNA biology · 2013Review
- Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.Genome research · 2010Article
- A conserved motif of vertebrate Y RNAs essential for chromosomal DNA replication.RNA (New York, N.Y.) · 2009Article
- Structured non-coding RNAs and the RNP Renaissance.Current opinion in chemical biology · 2008Review
- Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation.British journal of cancer · 2008Article
- Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.Genes & development · 2007Article
- Evolution of the vertebrate Y RNA cluster.Theory in biosciences = Theorie in den Biowissenschaften · 2007Article
- Human La is found at RNA polymerase III-transcribed genes in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Retropseudogenes derived from the human Ro/SS-A autoantigen-associated hY RNAs.Nucleic acids research · 2005Article
- Heterogeneity of human Ro ribonucleoproteins (RNPS): nuclear retention of Ro RNPS containing the human hY5 RNA in human and mouse cells.Clinical and experimental immunology · 2001Article
- Comparison of the RNA polymerase III transcription machinery in Schizosaccharomyces pombe, Saccharomyces cerevisiae and human.Nucleic acids research · 2001Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ro ribonucleoproteins are composed of Y RNAs and the Ro 60 kDa protein. While the Ro 60 kDa protein is implicated in an RNA discard pathway that recognizes 3'-extended 5S rRNAs, the function of Y RNAs remains unknown [O'Brien,C.A. and Wolin,S.L. (1995) Genes Dev. 8,2891-2903]. Y5 RNA occupies a large fraction of Ro 60 kDa protein in human Ro RNPs, contains an atypical 3'-extension not found on other Y RNAs, and constitutes an RNA antigen in certain autoimmune patients [Boulanger et al. (1995) Clin. Exp. Immunol. 99, 29-36]. An overabundance of Y RNA retroposed pseudogenes has previously complicated the isolation of mammalian Y RNA genes. The source gene for Y5 RNA was isolated from human DNA as well as from Galago senegalis DNA. Authenticity of the hY5 RNA gene was demonstrated in vivo and its activity was compared with the hY4 RNA gene that also uses a type 3 promoter for RNA polymerase III. The hY5 RNA gene was subsequently found to reside within a few hundred thousand base pairs of other Y RNA genes and the linear order of the four human Y RNA genes on chromosome 7q36 was determined. Phylogenetic comparative analyses of promoter and RNA structure indicate that the Y5 RNA gene has been subjected to positive selection during primate evolution. Consistent with the proposal of O'Brien and Harley [O'Brian,C.A. and Wolin,S.L. (1992) Gene 116, 285-289], analysis of flanking sequences suggest that the hY5 RNA gene may have originated as a retroposon.
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Registered trials
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