ArticleNucleic acids research1996
The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- Comprehensive mutational analysis of the checkpoint signaling function of Rpa1/Ssb1 in fission yeast.PLoS genetics · 2023Article
- Comprehensive mutational analysis of the checkpoint signaling function of Rpa1/Ssb1 in fission yeast.bioRxiv : the preprint server for biology · 2023Article
- Protein fluorescent labeling in live yeast cells using scFv-based probes.Cell reports methods · 2022Article
- Review
- The Intra-S Checkpoint Responses to DNA Damage.Genes · 2017Review
- Role of Deubiquitinating Enzymes in DNA Repair.Molecular and cellular biology · 2016Review
- Managing Single-Stranded DNA during Replication Stress in Fission Yeast.Biomolecules · 2015Review
- Article
- Article
- Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Cellular and molecular life sciences : CMLS · 2012Review
- Differential chromatin proteomics of the MMS-induced DNA damage response in yeast.Proteome science · 2011Article
- Common mechanisms of PIKK regulation.DNA repair · 2009Review
- Article
- Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA).The Journal of biological chemistry · 2008Article
- Mechanisms of cell cycle control revealed by a systematic and quantitative overexpression screen in S. cerevisiae.PLoS genetics · 2008Article
- Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints.The Journal of biological chemistry · 2008Article
- Article
- Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses.Journal of cellular physiology · 2006Review
- Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells.Oncogene · 2005Article
- Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling.Genes & development · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rfa1-M2 and rfa1-M4 Saccharomyces cerevisiae mutants, which are altered in the 70 kDa subunit of replication protein A (RPA) and sensitive to UV and methyl methane sulfonate (MMS), have been analyzed for possible checkpoint defects. The G1/S and intra-S DNA damage checkpoints are defective in the rfa1-M2 mutant, since rfa1-M2 cells fail to properly delay cell cycle progression in response to UV irradiation in G1 and MMS treatment during S phase. Conversely, the G2/M DNA damage checkpoint and the S/M checkpoint are proficient in rfa1-M2 cells and all the checkpoints tested are functional in the rfa1-M4 mutant. Preventing S phase entry by alpha-factor treatment after UV irradiation in G1 does not change rfa1-M4 cell lethality, while it allows partial recovery of rfa1-M2 cell viability. Therefore, the hypersensitivity to UV and MMS treatments observed in the rfa1-M4 mutant might only be due to impairment of RPA function in DNA repair, while the rfa1-M2 mutation seems to affect both the DNA repair and checkpoint functions of Rpa70.
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