ArticleJournal of molecular neuroscience : MN1996
Alternative splicing of the Brn-3a and Brn-3b transcription factor RNAs is regulated in neuronal cells.
Article in Journal of molecular neuroscience : MN, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- OCT2 expression in histiocytoses.Virchows Archiv : an international journal of pathology · 2023Article
- POU4F2/Brn-3b transcription factor is associated with survival and drug resistance in human ovarian cancer cells.Oncotarget · 2018Article
- Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes.American journal of physiology. Endocrinology and metabolism · 2016Article
- RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.Molecular vision · 2013Article
- Characterization of glucagon-expressing neurons in the chicken retina.The Journal of comparative neurology · 2006Article
- Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells.Journal of molecular neuroscience : MN · 2005Article
- Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor.Oncogene · 2003Article
- Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter.Nucleic acids research · 2002Article
- A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53.Nucleic acids research · 2001Article
- Article
- The N-terminal domain unique to the long form of the Brn-3a transcription factor is essential to protect neuronal cells from apoptosis and for the activation of Bbcl-2 gene expression.Nucleic acids research · 1998Article
- POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.Molecular and cellular biology · 1998Article
- The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins.Molecular and cellular biology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The closely related and functionally antagonistic POU family transcription factors Brn-3a and Brn-3b are encoded by two distinct genes that are expressed primarily in neuronal cells. In addition, however, the primary transcript of each of these genes is alternatively spliced to produce two distinct mRNAs encoding long and short isoforms that differ at the N-terminus of the protein. We show that this process is regulated so that different proportions of the mRNAs encoding the long and short forms of either Brn-3a or Brn-3b are produced in different rat tissues. Similarly, the ratio of each of these forms can be modulated by specific stimuli in both a neuronal cell line and primary neurons. The significance of these effects is discussed in relation to the functional differences between the two forms of each factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.