ReviewJournal of molecular medicine (Berlin, Germany)1996
IL-6 cytokine family and signal transduction: a model of the cytokine system.
Review in Journal of molecular medicine (Berlin, Germany), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Salivary Immune and Endocrine Biomarkers in Skin and Mucocutaneous Diseases.Advances in experimental medicine and biology · 2026Review
- SolarplastInternational journal of molecular sciences · 2024Article
- Neurotrophic factors in the porcine ovary: Their effects on follicular growth, oocyte maturation, and developmental competence.Frontiers in veterinary science · 2022Review
- On the role of bacterial metalloproteases in COVID-19 associated cytokine storm.Cell communication and signaling : CCS · 2021Article
- Mitigation of Rheumatic Arthritis in a Rat Model via Transdermal Delivery of Dapoxetine HCl Amalgamated as a Nanoplatform: In vitro and in vivo Assessment.International journal of nanomedicine · 2020Article
- Up-regulation of MIAT aggravates the atherosclerotic damage in atherosclerosis mice through the activation of PI3K/Akt signaling pathway.Drug delivery · 2019Article
- Current Knowledge of IL-6 Cytokine Family Members in Acute and Chronic Kidney Disease.Biomedicines · 2019Review
- Co-Expression of VEGF and IL-6 Family Cytokines is Associated with Decreased Survival in HER2 Negative Breast Cancer Patients: Subtype-Specific IL-6 Family Cytokine-Mediated VEGF Secretion.Translational oncology · 2019Article
- Effects of Graphene Oxide Nanoparticles on the Immune System Biomarkers Produced by RAW 264.7 and Human Whole Blood Cell Cultures.Nanomaterials (Basel, Switzerland) · 2018Article
- Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice.Frontiers in pharmacology · 2018Article
- Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study.Central-European journal of immunology · 2018Review
- JAK1/STAT3 Activation through a Proinflammatory Cytokine Pathway Leads to Resistance to Molecularly Targeted Therapy in Non-Small Cell Lung Cancer.Molecular cancer therapeutics · 2017Article
- Identifying the association between interleukin-6 and lichen planus: A meta-analysis.Biomedical reports · 2017Article
- Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-κB, ERK and JNK signaling pathways.Scientific reports · 2017Article
- Phosphorylation of STAT3 at Tyr705 regulates MMP-9 production in epithelial ovarian cancer.PloS one · 2017Article
- The Antidiabetic Activity ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Anti-inflammatory activity of ethanolic extract from skipjack tuna (Food science and biotechnology · 2016Article
- Neuroprotective effect of interleukin-6 in a rat model of cerebral ischemia.Experimental and therapeutic medicine · 2015Article
- Effect of Compound Chuanxiong Capsule on Inflammatory Reaction and PI3K/Akt/NF-κB Signaling Pathway in Atherosclerosis.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Heart regeneration, stem cells, and cytokines.Regenerative medicine research · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interleukin 6 (IL-6) cytokine family, which includes IL-6, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), IL-11 and cardiotrophin-1 (CT-1), exhibits pleiotropy and redundancy in biological activities. The IL-6 family cytokines exhibit a helical structure. Their receptors belong to the type 1 cytokine receptor family. The receptors of the IL-6 family cytokines share a receptor subunit, which explains one of the mechanisms of functional redundancy. In this review, we describe the general features of the IL-6 cytokine family and its signal transduction mechanisms. Many functional properties of the IL-6 family of cytokines and their receptors are general features of the cytokine system.
Indexed as
Identifiers
8834766What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.