ArticleHuman genetics1996
An unusual dicentric Y chromosome with a functional centromere with no detectable alpha-satellite.
Article in Human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Maternal CENP-C restores centromere symmetry in mammalian zygotes to ensure proper chromosome segregation.Developmental cell · 2026Article
- Article
- Article
- Epigenetic origin of evolutionary novel centromeres.Scientific reports · 2017Article
- Centromere repositioning in mammals.Heredity · 2012Review
- Formation of novel CENP-A domains on tandem repetitive DNA and across chromosome breakpoints on human chromosome 8q21 neocentromeres.Chromosoma · 2011Article
- Neocentromeres: new insights into centromere structure, disease development, and karyotype evolution.American journal of human genetics · 2008Review
- Recurrent sites for new centromere seeding.Genome research · 2004Article
- Human centromere repositioning "in progress".Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Neocentromeres: role in human disease, evolution, and centromere study.American journal of human genetics · 2002Review
- Molecular cytogenetic analysis of eight inversion duplications of human chromosome 13q that each contain a neocentromere.American journal of human genetics · 2000Review
- Transmission of a fully functional human neocentromere through three generations.American journal of human genetics · 1999Article
- A molecular and FISH analysis of structurally abnormal Y chromosomes in patients with Turner syndrome.Journal of medical genetics · 1999Article
- Neocentromeres, the Y chromosome and centromere evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1998Article
- Centromere DNA dynamics: latent centromeres and neocentromere formation.American journal of human genetics · 1997Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe an unusual marker chromosome Y. This marker is present in 5% of the lymphocytes of a dysgenetic woman showing a mosaic karyotype 45,X/46,XY/47,XY+mar. Q-banding revealed that the marker was morphologically identical to the Y chromosome of the patient but presented the primary constriction in the heterochromatic region. C-banding confirmed that the heterochromatic region was C-positive; furthermore, it showed two spots in the euchromatic region in a position corresponding to that of the centromere in the normal Y. Fluorescence in situ hybridization with the centromere-specific probe pDP 97 and the pancentromeric alpha-satellite probe alpha 27 alpha 30 failed to detect any signal at the primary constriction site. To improve the characterization of the marker chromosome, hybridization was performed using pDP 105, a probe located on the short arm of the Y chromosome, together with chromosome-Y-specific paint-hybridizing to the single sequence spanning the Y short arm. In both cases, positive signals telomeric to the inactive centromere were observed. Possible mechanisms resulting in the formation of the marker chromosome are discussed.
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