ArticleThe Journal of clinical investigation1996
An in vitro assay for detection of glomerular binding IgG autoantibodies in patients with systemic lupus erythematosus.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus.Nature communications · 2023Article
- Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs.PLoS biology · 2018Article
- A peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigens.Clinical and experimental immunology · 2016Article
- The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?Seminars in nephrology · 2015Review
- Article
- Autoantibodies in systemic autoimmune diseases: specificity and pathogenicity.The Journal of clinical investigation · 2015Review
- Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production.European journal of immunology · 2015Article
- Biomarkers for kidney involvement in pediatric lupus.Biomarkers in medicine · 2015Review
- Mesangial cell-binding activity of serum immunoglobulin g in patients with lupus nephritis.PloS one · 2014Article
- Anti-DNA antibodies cross-react with C1q.Journal of autoimmunity · 2013Article
- The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies.Journal of autoimmunity · 2012Article
- Identification of a lipid peroxidation product as the source of oxidation-specific epitopes recognized by anti-DNA autoantibodies.The Journal of biological chemistry · 2010Article
- The role of B cells in lupus pathogenesis.The international journal of biochemistry & cell biology · 2010Review
- Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.The Journal of clinical investigation · 2009Article
- Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays.The Journal of clinical investigation · 2005Article
- Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice.The Journal of experimental medicine · 2004Article
- CTLA4Ig inhibits T cell-dependent B-cell maturation in murine systemic lupus erythematosus.The Journal of clinical investigation · 2000Article
- Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies.The Journal of clinical investigation · 1999Article
- B cells and autoantibodies in the pathogenesis of lupus nephritis.Immunologic research · 1998Review
- Autoantibody to the nucleosome subunit (H2A-H2B)-DNA is an early and ubiquitous feature of lupus-like conditions.Molecular biology reports · 1996Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The deposition of anti-dsDNA antibodies in the glomerulus is believed to play a critical role in the pathogenesis of nephritis in SLE. However, an absolute correlation between serum levels of anti-dsDNA antibodies and renal disease has not been found. Recently a glomerular binding assay (GBA) has been developed to detect IgG binding to isolated rat glomeruli. We have used the GBA to study sera from four groups of SLE patients: (A) + anti-dsDNA antibodies, active nephritis; (B) - anti-dsDNA antibodies, active nephritis; (C) + anti-dsDNA antibodies, no nephritis; and (D) - anti-dsDNA antibodies, no nephritis. The serum anti-dsDNA antibodies in group A and group C patients could not be distinguished on the basis of isotype, charge, or cross-reactivity with histones. Nevertheless, the mean intensity of glomerular immunofluorescence was significantly higher in group A than in the three other patient groups and distinguished between patients with serum anti-dsDNA antibodies who had nephritis and those without clinically apparent nephritis. GBA reactivity was unaffected by DNase treatment of sera, but was partially inhibited by preincubation with dsDNA. These findings are consistent with the hypothesis that some anti-dsDNA antibodies cross-react with glomerular components and that the presence of this cross-reactivity is associated with, and may be responsible for, the development of nephritis. In addition, we have identified a group of SLE patients with renal disease and typical renal histopathology and immune deposits who do not have serum anti-dsDNA antibodies or antibodies that directly bind to glomeruli in the GBA. The mechanism of renal immune deposition in these patients remains to be determined.
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Registered trials
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