ArticleThe Journal of cell biology1996
Association between a transmembrane protein tyrosine phosphatase and the cadherin-catenin complex.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 245 citations in OpenAlex.
- To Stick or Not to Stick: Adhesions in Orofacial Clefts.Biology · 2022Review
- LAR Receptor Tyrosine Phosphatase Family in Healthy and Diseased Brain.Frontiers in cell and developmental biology · 2021Review
- Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study.Molecular & cellular proteomics : MCP · 2016Article
- The Drosophila Receptor Protein Tyrosine Phosphatase LAR Is Required for Development of Circadian Pacemaker Neuron Processes That Support Rhythmic Activity in Constant Darkness But Not during Light/Dark Cycles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses.Seminars in cell & developmental biology · 2015Review
- Netrin-G/NGL complexes encode functional synaptic diversification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Asymmetric N-cadherin expression results in synapse dysfunction, synapse elimination, and axon retraction in cultured mouse neurons.PloS one · 2013Article
- Receptor type protein tyrosine phosphatases (RPTPs) - roles in signal transduction and human disease.Journal of cell communication and signaling · 2012Article
- The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.Development (Cambridge, England) · 2012Article
- The dynamic role of beta-catenin in synaptic plasticity.Neuropharmacology · 2012Review
- Regulation of adherens junction dynamics by phosphorylation switches.Journal of signal transduction · 2012Article
- WAVE2 Protein Complex Coupled to Membrane and Microtubules.Journal of oncology · 2012Article
- β-Pix modulates actin-mediated recruitment of synaptic vesicles to synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Receptor protein tyrosine phosphatases are novel components of a polycystin complex.Biochimica et biophysica acta · 2011Article
- Orchestrating the synaptic network by tyrosine phosphorylation signalling.Journal of biochemistry · 2011Review
- Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila.PLoS genetics · 2010Article
- Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting.Developmental biology · 2009Article
- KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules.Journal of cell science · 2009Article
- Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses.Nature neuroscience · 2009Article
- Not so simple: the complexity of phosphotyrosine signaling at cadherin adhesive contacts.Journal of molecular medicine (Berlin, Germany) · 2007Review
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cadherins are calcium-dependent cell adhesion molecules that play fundamental roles in embryonic development, tissue morphogenesis, and cancer. A prerequisite for their function is association with the actin cytoskeleton via the catenins. Tyrosine phosphorylation of beta-catenin, which correlates with a reduction in cadherin-dependent cell adhesion, may provide cells with a mechanism to regulate cadherin activity. Here we report that beta-catenin immune precipitates from PC12 cells contain tyrosine phosphatase activity which dephosphorylates beta-catenin in vitro. In addition, we show that a member of the leukocyte antigen-related protein (LAR)-related transmembrane tyrosine phosphatase family (LAR-PTP) associates with the cadherin-catenin complex. This association required the amino-terminal domain of beta-catenin but does not require the armadillo repeats, which mediate association with cadherins. The interaction also is detected in PC9 cells, which lack alpha-catenin. Thus, the association is not mediated by alpha-catenin or by cadherins. Interestingly, LAR-PTPs are phosphorylated on tyrosine in a TrkA-dependent manner, and their association with the cadherin-catenin complex is reduced in cells treated with NGF. We propose that changes in tyrosine phosphorylation of beta-catenin mediated by TrkA and LAR-PTPs control cadherin adhesive function during processes such as neurite outgrowth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.